Hitting HIV’s Harpoon Immunity Marit J. van Gils, Rogier W. Sanders  Immunity  Volume 49, Issue 1, Pages 14-15 (July 2018) DOI: 10.1016/j.immuni.2018.07.003 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Focusing on the Fusion Peptide of the HIV-1 Envelope Glycoprotein Top: Homing in on the FP of HIV-1 and the role of the FP in the fusion of viral and cellular membranes. Bottom: Immunization of mice resulted in antibodies that neutralized heterologous virus strains but with lower potency and breadth compared to human bNAbs. Immunization of NHPs resulted in serum activity that neutralized up to 20% of heterologous strains. Abbreviations: FP, fusion peptide; MAb, monoclonal antibody; IC50, 50% inhibitory concentration; ID50, 50% inhibitory reciprocal serum dilution. Immunity 2018 49, 14-15DOI: (10.1016/j.immuni.2018.07.003) Copyright © 2018 Elsevier Inc. Terms and Conditions