Anti-Flk-1 mAb treatment reduces vessel density in tumors.

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Anti-Flk-1 mAb treatment reduces vessel density in tumors. Anti-Flk-1 mAb treatment reduces vessel density in tumors. A, A431 tumors from mice treated with control IgG or DC101 were resected after 1 week of antibody treatment, fixed, paraffin-embedded and sectioned at 7 um. Vessels were stained with biotinylated anti-PECAM antibody and visualized using streptavidin-HRP and DAB substrate. Endothelial cells and vessels (brown) were significantly reduced in DC101-treated tumors. ×200. B, A431 tumors from mice treated with control IgG or DC101 were resected after 1 (□) and 2 (▪) weeks of antibody treatment and stained with anti-PECAM as described above. Microvessel density was quantitated by image analysis of stained sections as described in “ Materials and Methods.” A significant reduction (P < 0.01 versus control) in microvessel density was observed in the DC101 group after 1 and 2 weeks of treatment. Columns, mean; bars, SE. Marie Prewett et al. Cancer Res 1999;59:5209-5218 ©1999 by American Association for Cancer Research