Cisplatin plus PTUPB decreases proliferation and angiogenesis but increases apoptosis as determined by immunohistochemical (IHC) analysis. Cisplatin plus.

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Cisplatin plus PTUPB decreases proliferation and angiogenesis but increases apoptosis as determined by immunohistochemical (IHC) analysis. Cisplatin plus PTUPB decreases proliferation and angiogenesis but increases apoptosis as determined by immunohistochemical (IHC) analysis. Formalin-fixed paraffin-embedded PDX BL0293 tumor sections were stained for H&E, Ki-67, cleaved caspase-3, and CD31. More Ki-67 positive cells were observed in the control group, but significantly decreased in the combination group. Compared with the control group, increasing numbers of cells stained positive for cleaved caspase-3 were observed in the PTUPB, cisplatin, and PTUPB plus cisplatin combination groups. CD31 staining was decreased in PTUPB and combination groups. Quantitative data of Ki67, cleaved caspase-3, and CD31 staining in each group were generated from randomly selected 20 fields and are shown along with the images. *: P < 0.05. Fuli Wang et al. Mol Cancer Ther 2018;17:474-483 ©2018 by American Association for Cancer Research