Electron microscopy. Electron microscopy. A, 8 h after irradiation. An endothelial cell is seen protruding into the lumen of the vessel. Arrow head, a.

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Electron microscopy. Electron microscopy. A, 8 h after irradiation. An endothelial cell is seen protruding into the lumen of the vessel. Arrow head, a gap between endothelial cells. B, untreated control. The endothelium is continuous with tight junctions between endothelial cells (arrowhead) and a normal basal membrane (arrow). C, TNP-470-treated tumor. Arrow, an approximately 400–700-nm endothelial basement membrane-related, electron-dense material; l, leukocyte in vessel lumen; t, tumor cell; e, endothelial cell. Eva L. Lund et al. Clin Cancer Res 2000;6:971-978 ©2000 by American Association for Cancer Research