Connective tissue Glycosaminoglycan Collagen.

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Presentation transcript:

Connective tissue

Glycosaminoglycan

Collagen

Collagen Type Molecule Structural Features Representative Tissues Composition Fibrillar Collagens I [α1(I)]2[α2(I)] 300-nm-long fibrils Skin, tendon, bone, ligaments, dentin, interstitial tissues II [α1(II)]3 300-nm-long fibrils Cartilage, vitreous humor III [α1(III)]3 300-nm-long fibrils; Skin, muscle, blood vessels often with type I V [α1(V)]3 390-nm-long fibrils with Similar to type I; also cell globular N-terminal cultures, fetal tissues domain; often with type I Fibril-Associated Collagens VI [α1(VI)][α2(VI)] Lateral association with Most interstitial tissues type I; periodic globular domains IX [α1(IX)][α2(IX)] Lateral association with Cartilage, vitreous humor [α3(IX)] type II; N-terminal globular domain; bound glycosaminoglycan Sheet-Forming Collagens IV [α1(IV)]2[α2(IV)] Two-dimensional network All basal laminaes

Bone

Bone marrow

Hematopoiesis

Neuron

Synapse

Sarcoplasmic reticulum

Take home message Neuronal structure Neuromuscular junction