Biogenesis of the Legionella-containing vacuole (LCV).

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Biogenesis of the Legionella-containing vacuole (LCV). Biogenesis of the Legionella-containing vacuole (LCV). Following phagocytosis through PI-3-kinase-dependent and/or -independent mechanisms (a), within minutes, the nascent LCV avoids interactions with endosomes, fuses transiently with mitochondria, and intercepts ER exit vesicles bearing COP II markers (b). For the next several hours, the LCV maintains interactions with ER-derived vesicles, and the bacteria replicate in a vacuole surrounded by a membrane that resembles rough ER (c). Hayley J. Newton et al. Clin. Microbiol. Rev. 2010; doi:10.1128/CMR.00052-09