MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting Sox2. MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting.

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MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting Sox2. MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting Sox2. A, effects of miR-200c and miR-200c/Sox2 on subcutaneous tumor generation (n = 6). B, tumor sizes were measured on the indicated days (d). Data, mean tumor volume ± SD. C, representative images of the whole body, hepatic metastases, and hematoxylin and eosin (H&E) stains of metastatic livers of mice in the orthotropic metastasis assay (n = 5 per group). Scale bar, 100 μm. **, P < 0.01; ***, P < 0.001. Yan-Xia Lu et al. Clin Cancer Res 2014;20:2631-2642 ©2014 by American Association for Cancer Research