MiR-200c is a PI3K–AKT signaling pathway regulator in CRC

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MiR-200c is a PI3K–AKT signaling pathway regulator in CRC MiR-200c is a PI3K–AKT signaling pathway regulator in CRC. A, Western blot analyses of p-PI3K, T-PI3K, p-AKT, and T-AKT in the cells as indicated. MiR-200c is a PI3K–AKT signaling pathway regulator in CRC. A, Western blot analyses of p-PI3K, T-PI3K, p-AKT, and T-AKT in the cells as indicated. B, Western blot analyses of indicated proteins in SW480 and HCT116 knockdown of miR-200c, followed by the treatment of LY294002. GAPDH served as the loading control. C, proposed model of how miR-200c regulates CRC proliferation and metastasis through regulation of Sox2. Yan-Xia Lu et al. Clin Cancer Res 2014;20:2631-2642 ©2014 by American Association for Cancer Research