IL-13Rα2 expression is associated to human colon cancer progression and poor survival of patients with colorectal cancer. IL-13Rα2 expression is associated.

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IL-13Rα2 expression is associated to human colon cancer progression and poor survival of patients with colorectal cancer. IL-13Rα2 expression is associated to human colon cancer progression and poor survival of patients with colorectal cancer. A, immunohistochemical analysis of IL-13 expression in human CRC tissue showed that IL-13 expression occurs preferentially in CRC epithelial cells. B, immunohistochemical analysis of IL-13Rα2 expression in TMAs showing representative images of strong, moderate, or negative staining of different colon carcinomas and negative normal paired mucosa. Counterstaining was made with hematoxylin. Photographs were taken at ×200 magnification. C, quantification of IL-13Rα2 expression by estimation of staining intensity was carried out as described in Materials and Methods. Eighty samples were analyzed. Positive and negative values were represented as bar graphs. P values were calculated with the χ2 test. D, Kaplan–Meier analyses of overall survival of patients with cancer according to the expression of IL-13Rα2. Significant association of IL-13Rα2 expression with lower overall survival was found by comparing differences between curves with the log-rank test. Rodrigo Barderas et al. Cancer Res 2012;72:2780-2790 ©2012 by American Association for Cancer Research