Fig. 1 Structure of the α-SNAP–SNARE subcomplex.

Slides:

Advertisements

Similar presentations

Fig. 2 Chiral and achiral structures of formic acid.

Advertisements

Fig. 2 Transport properties of a BP transistor at low temperature.

Fig. 4 Ballistic simulation of BP FETs.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 1 Map of water stress and shale plays.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 3 Electron PSD in various regions.

Fig. 4 Complete separation of water and solute after stable and efficient solar evaporation. Complete separation of water and solute after stable and efficient.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 6 Comparison of properties of water models.

Fig. 2 Reference-fixing experiment, results.

Fig. 3 Scan rate effects on the layer edge current.

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 1 Cryo-EM structure of yeast Elp123 showing its active site.

Fig. 1 Reference-fixing experiment, setup.

Fig. 5 Computational investigations of oxygen ion diffusion and electrical conduction in ZnxCo1−xO. Computational investigations of oxygen ion diffusion.

Fig. 1 Bioinspired design of AAD for promoting wound contraction.

Fig. 3 Affective responses by exchange condition (PR and RE), level of redistribution (0 = random, one-card, and two-card exchange), and outcome as winner.

Fig. 1 Proportions of normative beliefs by exchange condition, level of redistribution (0 = random, one-card, and two-card exchange), and outcome as winner.

Fig. 1 Distribution of total and fake news shares.

Fig. 3 Forward model. Forward model. Summary of the resampled Monte Carlo simulations shown as histograms for epoch 1 (red), epoch 2 (green), and epoch.

Fig. 3 Photon number statistics resulting from Fock state |l, S − l〉 interference. Photon number statistics resulting from Fock state |l, S − l〉 interference.

Fig. 1 The illustration of discontinuous hydrogen bonding chains in FJU-23-H2O. The illustration of discontinuous hydrogen bonding chains in FJU-23-H2O.

Fig. 2 2D QWs of different propagation lengths.

Fig. 1 Map of the study area including the northwestern end of the Hawaiian Ridge and the southern portion of the ESC. Map of the study area including.

Electronic structure of the oligomer (n = 8) at the UB3LYP/6-31G

Fig. 4 DFT ωB97x/def2-TZVPP atomic charges on the sulfur atom of substituted thioaldehyde and AIMNet prediction with a different number of iterative passes.

Fig. 1 Data collection at a 40° tilt angle enabled reconstruction of a cryo-EM map of the NRTN-GFRα2-RET complex at a 5.7-Å resolution. Data collection.

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 5 Wave speed analysis.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 4 Two-color photoinitiation and photoinhibition enable controllable, far-surface patterning of complex 3D structures. Two-color photoinitiation and.

Fig. 4 Praying Prophet by Lorenzo Monaco: Mapping lake pigments and associated substrate. Praying Prophet by Lorenzo Monaco: Mapping lake pigments and.

Contrast agent uptake for the four different groups of MMA mice

Fig. 4 Visualization of complex loop motions by 1-μs MD trajectories.

Fig. 2 Folding motions of the TCO with strain-softening behavior.

Fig. 2 Schematic drawings of Göbekli Tepe skulls.

Fig. 1 Experiment description.

Fig. 4 Relationships between light and economic parameters.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Fig. 3 Relationships between Q10 and C distribution in aggregates.

Fig. 4 BS-SEM images, ternary diagrams, and phase maps for the text and reverse sides of the TS. BS-SEM images, ternary diagrams, and phase maps for the.

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 4 Map of δ18OVSMOW in groundwaters of the British Isles (left) and Strontium (87Sr/86Sr) biosphere map of Great Britain (right). Map of δ18OVSMOW.

Fig. 2 Simulations of possible doping positions and band structures.

Fig. 4 Phase diagram showing significant order parameters ∣pk∣ versus T and wc. Phase diagram showing significant order parameters ∣pk∣ versus T and wc.

Multiplexed four- and eight-channel devices for rapid processing

Fig. 2 RVFV causes pathology within the liver, uterus, and placenta of pregnant dams. RVFV causes pathology within the liver, uterus, and placenta of pregnant.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Fig. 3 Electrochemical performances of symmetric cells using control Li and composite Li electrodes. Electrochemical performances of symmetric cells using.

Fig. 4 Mapping of abundance of the most dominant bacterial and archaeal phyla across France. Mapping of abundance of the most dominant bacterial and archaeal.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 1 Chemical structures of the bioconjugates.

Fig. 4 Single-particle contact angle measurements.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

Fig. 1 Design principle and SEM characterization of super-origami DNA nanostructures with n-tuples. Design principle and SEM characterization of super-origami.

Fig. 2 Daily TNC pickups and drop-offs for an average Wednesday in fall 2016 (1). Daily TNC pickups and drop-offs for an average Wednesday in fall 2016.

Fig. 3 Rural-urban gap of per capita income in China from 1978 to Rural-urban gap of per capita income in China from 1978 to The income of.

Fig. 4 Effects of individual picosecond and microsecond pulses.

Fig. 3 Calculated electronic structure of ZrCoBi.

Fig. 2 Direct and indirect effects of richness, total abundance, and evenness on ecosystem services. Direct and indirect effects of richness, total abundance,

Fig. 1 Atomic structure of U1−xThxSb2.

Fig. 4 Orthosteric ligand-binding pocket in CysLT1R.

Presentation transcript:

Fig. 1 Structure of the α-SNAP–SNARE subcomplex. Structure of the α-SNAP–SNARE subcomplex. (A) The EM density map of the α-SNAP–SNARE subcomplex color-coded to show the local resolution as estimated by ResMap. The right panel shows a cut-through view of the interior of the map. (B) Cryo-EM density (mesh) of representative layers of the SNARE complex superimposed with respective atomic models (stick). Unsharpened map showing the extended density corresponding to the longer C terminus of VAMP is displayed in the inset. The red arrows indicate the extended density. (C) Interactions of each α-SNAP with the SNARE complex showing interacting residues. Eye symbols and arrowheads in the insets indicate view directions. Note that each α-SNAP molecule interacts with three of the four chains of the SNARE complex, and in each of the four α-SNAP molecules, almost an identical set of residues make contact with SNARE, but on the receiving side, different sets of residues are used by individual SNARE chains. Xuan Huang et al. Sci Adv 2019;5:eaau8164 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).