Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough Dominik Hartl, MD, Matthias Griese, MD, Thomas Nicolai,

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Presentation transcript:

Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough Dominik Hartl, MD, Matthias Griese, MD, Thomas Nicolai, MD, Gernot Zissel, PhD, Christine Prell, MD, Nikolaos Konstantopoulos, MD, Rudolf Gruber, MD, Dietrich Reinhardt, MD, Dolores J. Schendel, PhD, Susanne Krauss-Etschmann, MD Journal of Allergy and Clinical Immunology Volume 115, Issue 4, Pages 728-736 (April 2005) DOI: 10.1016/j.jaci.2004.11.049 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Lymphocyte gating in BALF according to FSC/SCC characteristics is hampered by cellular overlay (A). Therefore lymphocytes were identified by the surface expression of CD8 (B) and then gated back into an FSC/SSC plot (C). Because CD4+ and CD8+ lymphocytes have identical FSC/SCC characteristics, the cells falling into this FSC/SSC gate (Fig 1, C) were used for further phenotypic analyses (D and E). Journal of Allergy and Clinical Immunology 2005 115, 728-736DOI: (10.1016/j.jaci.2004.11.049) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Percentages of CD4+ and CD8+ T cells and CD4/CD8 ratios in BALF of asthmatic patients (A), patients with chronic cough (CC), and control patients (CO). Median values are shown by horizontal bars. Differences between the patient groups were tested with the Mann-Whitney U test (∗P < .05). Journal of Allergy and Clinical Immunology 2005 115, 728-736DOI: (10.1016/j.jaci.2004.11.049) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Levels of the CCR4 (TH2) chemokines TARC and MDC (A); the CXCR3 (TH1) chemokines IP-10, Mig, and ITAC (B); and IL-4, IL-5, and IFN-γ (C) in BALF of asthmatic patients (A), patients with chronic cough (CC), and control patients (CO). Median values are shown by horizontal bars. Differences between the patient groups were tested with the Mann-Whitney U test (∗P < .05, ∗∗∗P < .001). Journal of Allergy and Clinical Immunology 2005 115, 728-736DOI: (10.1016/j.jaci.2004.11.049) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Percentages of CXCR3+CD8+ (TH1) and CCR4+CD4+ (TH2) double-positive cells in BALF of asthmatic patients (A), patients with chronic cough (CC), and control patients (CO). Median values are shown by horizontal bars. Differences between the patient groups were tested with the Mann-Whitney U test (∗∗P < .01). Journal of Allergy and Clinical Immunology 2005 115, 728-736DOI: (10.1016/j.jaci.2004.11.049) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 Correlations between percentages of CCR4+CD4+ T cells, levels of TARC (A), levels of MDC (B), and FEV1 (C). The regression line and the correlation coefficient are only shown for children with asthma. Journal of Allergy and Clinical Immunology 2005 115, 728-736DOI: (10.1016/j.jaci.2004.11.049) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 6 Correlation between levels of ITAC and percentages of CXCR3+CD8+ T cells. The regression line and the correlation coefficient are only shown for children with chronic cough. Journal of Allergy and Clinical Immunology 2005 115, 728-736DOI: (10.1016/j.jaci.2004.11.049) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions