IL-13Rα2 promotes cell survival and proliferation.

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Presentation transcript:

IL-13Rα2 promotes cell survival and proliferation. IL-13Rα2 promotes cell survival and proliferation. A, cells were incubated with H2O2 for 16 hours in presence of medium alone or with IL-13, and in presence or absence of LY294002 inhibitor or anti-IL-13Rα2 antibodies, and subjected to apoptosis detection assays. B, colony formation assay in soft agar with the indicated cell lines. C, proliferation and cell viability was determined by MTT assays after 24 to 48 hours of incubation in medium with or without IL-13 (10 ng/mL) and anti-IL-13Rα2 antibody. Optical density was significantly increased by addition of IL-13 (*, P < 0.05; **, P < 0.01) and significantly inhibited by anti-IL-13Rα2 (Δ, P < 0.05; ΔΔ, P < 0.01). Rodrigo Barderas et al. Cancer Res 2012;72:2780-2790 ©2012 by American Association for Cancer Research