Volume 23, Issue 16, Pages (August 2013)

Slides:

Advertisements

Similar presentations

Multiple sclerosis genetics

Advertisements

Michael Dannemann, Janet Kelso The American Journal of Human Genetics

Blanca E. Himes, Gary M. Hunninghake, James W. Baurley, Nicholas M

Comprehensively Evaluating cis-Regulatory Variation in the Human Prostate Transcriptome by Using Gene-Level Allele-Specific Expression Nicholas B. Larson,

Volume 22, Issue 9, Pages (May 2012)

The Genetic Basis of White Tigers

Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene Manfred Kayser, Fan Liu, A. Cecile J.W. Janssens,

Association of insulin receptor genetic variants with polycystic ovary syndrome in a population of women from Central Europe Felicia A. Hanzu, M.D.,

Genome-Wide Association Analysis Implicates Elastic Microfibrils in the Development of Nonsyndromic Striae Distensae Joyce Y. Tung, Amy K. Kiefer, Meghan.

Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time Lorna M. Houlihan, Gail Davies, Albert.

Gene Evolution: Getting Something from Nothing

Volume 26, Issue 7, Pages (April 2016)

Population Genomics: Finding the Variants of Mass Disruption

Lisette Arnaud-Lopez, Gianluca Usala, Graziano Ceresini, Braxton D

Volume 18, Issue 9, Pages (February 2017)

Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors Michael Dannemann, Aida M.

Volume 21, Issue 20, Pages R837-R838 (October 2011)

Volume 26, Issue 7, Pages (April 2016)

A Genomewide Association Study of Skin Pigmentation in a South Asian Population Renee P. Stokowski, P.V. Krishna Pant, Tony Dadd, Amelia Fereday, David.

Identification of a new locus at 16q12 associated with time to asthma onset Chloé Sarnowski, PhD, Pierre-Emmanuel Sugier, MSc, Raquel Granell, PhD, Debbie.

Volume 83, Issue 2, Pages (February 2013)

Volume 23, Issue 16, Pages (August 2013)

Volume 26, Issue 22, Pages (November 2016)

Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population S. Maeda, N. Osawa, T. Hayashi, S. Tsukada, M.

Volume 20, Issue 12, Pages (June 2010)

A 77-Kilobase Region of Chromosome 6p22

Visual Attention: Size Matters

Weight Loss after Gastric Bypass Is Associated with a Variant at 15q26

Gene-Expression Variation Within and Among Human Populations

Michael Dannemann, Janet Kelso The American Journal of Human Genetics

Volume 23, Issue 7, Pages R265-R266 (April 2013)

A Flexible Bayesian Framework for Modeling Haplotype Association with Disease, Allowing for Dominance Effects of the Underlying Causative Variants Andrew.

Human Evolution: Thrifty Genes and the Dairy Queen

Volume 24, Issue 8, Pages (April 2014)

Assessment of the Genetic Basis of Rosacea by Genome-Wide Association Study Anne Lynn S. Chang, Inbar Raber, Jin Xu, Rui Li, Robert Spitale, Julia Chen,

Volume 16, Issue 9, Pages (May 2006)

Volume 25, Issue 24, Pages (December 2015)

Volume 78, Issue 2, Pages (April 2013)

Gene Evolution: Getting Something from Nothing

Sriram Sankararaman, Swapan Mallick, Nick Patterson, David Reich

The Genetics of Seasonal Migration and Plumage Color

Volume 19, Issue 15, Pages (August 2009)

Whole-Genome Hitchhiking on an Organelle Mutation

Positive selection on gene expression in the human brain

Volume 21, Issue 16, Pages (August 2011)

A Three–Single-Nucleotide Polymorphism Haplotype in Intron 1 of OCA2 Explains Most Human Eye-Color Variation David L. Duffy, Grant W. Montgomery, Wei.

A Variant in LIN28B Is Associated with 2D:4D Finger-Length Ratio, a Putative Retrospective Biomarker of Prenatal Testosterone Exposure Sarah E. Medland,

Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association James R. Elmore, MD, Melissa.

Volume 380, Issue 9844, Pages (September 2012)

Volume 377, Issue 9766, Pages (February 2011)

Volume 26, Issue 17, Pages (September 2016)

Cetaceans on a Molecular Fast Track to Ultrasonic Hearing

Volume 15, Issue 14, Pages (July 2005)

Volume 22, Issue 1, Pages (January 2012)

Jared R. Kohler, David J. Cutler

A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function Manfei Zhang,

Volume 156, Issue 5, Pages e7 (April 2019)

Genome-Wide Association Study of Generalized Vitiligo in an Isolated European Founder Population Identifies SMOC2, in Close Proximity to IDDM8 Stanca.

Sriram Sankararaman, Swapan Mallick, Nick Patterson, David Reich

Volume 17, Issue 16, Pages (August 2007)

Volume 26, Issue 23, Pages (December 2016)

Genetic variants in the GATA3 gene are not associated with asthma and atopic diseases in German children Kathrin Suttner, MSc, Martin Depner, MSc, Norman.

Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time Lorna M. Houlihan, Gail Davies, Albert.

Sarah E. Medland, Dale R. Nyholt, Jodie N. Painter, Brian P

Volume 21, Issue 23, Pages (December 2011)

Evaluating the Effects of Imputation on the Power, Coverage, and Cost Efficiency of Genome-wide SNP Platforms Carl A. Anderson, Fredrik H. Pettersson,

Regional plot and genome browser view of 14q13.

Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors Michael Dannemann, Aida M.

Circadian Biology: The Early Bird Catches the Morning Shift

Beyond GWASs: Illuminating the Dark Road from Association to Function

Presentation transcript:

Volume 23, Issue 16, Pages 1596-1600 (August 2013) Identification of Regions Associated with Variation in Sensitivity to Food-Related Odors in the Human Genome Jeremy F. McRae, Sara R. Jaeger, Christina M. Bava, Michelle K. Beresford, Denise Hunter, Yilin Jia, Sok Leang Chheang, David Jin, Mei Peng, Joanna C. Gamble, Kelly R. Atkinson, Lauren G. Axten, Amy G. Paisley, Liam Williams, Leah Tooman, Benedicte Pineau, Simon A. Rouse, Richard D. Newcomb Current Biology Volume 23, Issue 16, Pages 1596-1600 (August 2013) DOI: 10.1016/j.cub.2013.07.031 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 Distributions of Detection Threshold Concentrations for Odors Tested in This Study (A) 1,8-cineole, (B) 2-heptanone, (C) hircinoic acid, (D) cis-3-hexen-1-ol, (E) dipropyl disulfide, (F) isobutyraldehyde, (G) isovaleric acid, (H) vanillin, (I) β-damascenone, and (J) β-ionone. Chemical structures of each odor compound are provided at the top of each distribution plot. See also Figure S1. Current Biology 2013 23, 1596-1600DOI: (10.1016/j.cub.2013.07.031) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 2 Manhattan Plots for the Four Odors with Significant Genetic Associations (A) 2-heptanone, (B) isobutyraldehyde, (C) β-damascenone, and (D) β-ionone. Alternate chromosomes are shown in alternating colors. Arrows indicate the locations of the best associated regions for each odor. See also Figure S2. Current Biology 2013 23, 1596-1600DOI: (10.1016/j.cub.2013.07.031) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 3 Regional Association Plots Showing Regions of Association Colocating with Clusters of Olfactory Receptor Genes For each of (A) 2-heptanone, (B) isobutyraldehyde, (C) β-damascenone, and (D) β-ionone regional variants are plotted according to their –log10 p value and chromosome position (GRCh37). Variants genotyped using SNP 6.0 arrays are shaded blue, and imputed variants are shaded gray. Estimated recombination rates from HapMap populations are plotted to show local linkage disequilibrium. The locations of genes within each associated region are shown beneath each association plot, with olfactory receptor (OR) genes shaded red. Non-OR gene annotations were obtained from the UCSC Genome browser, and OR gene annotations were obtained from the Human Olfactory Data Explorer database. Distributions of detection threshold concentrations by genotype for the strongest associated variants for each of the four odors are shown to the right of the regional association plots. See also Figure S3, Table S1, and Table S2. Current Biology 2013 23, 1596-1600DOI: (10.1016/j.cub.2013.07.031) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 4 Frequencies of Sensitivity Groups for 2-Heptanone, Isobutyraldehyde, β-Damascenone, and β-Ionone among 1000 Genomes Populations Sensitivity frequencies are predicted according to the frequency of the less sensitive genotype/s for each of rs9809531, rs13424612, rs2220004, and rs7943953, placed on the map according to the ancestral recruitment areas. See also Figure S4 and Tables S3–S6. Current Biology 2013 23, 1596-1600DOI: (10.1016/j.cub.2013.07.031) Copyright © 2013 Elsevier Ltd Terms and Conditions