Melanoma patient monocytes have altered expression of inflammatory and surface markers. Melanoma patient monocytes have altered expression of inflammatory.

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Melanoma patient monocytes have altered expression of inflammatory and surface markers. Melanoma patient monocytes have altered expression of inflammatory and surface markers. Cell surface markers on monocytes were measured by flow cytometry. Expression of cell surface markers on monocytes from malignant melanoma patients (MMP) and healthy volunteer controls (HV) for (A) costimulatory molecules CD80 and CD86 as a percentage of total monocytes; (B) MFI of TNFRII of total monocytes; (C) percentage of tissue factor positive of CD14+ monocytes; and (D) MFI of PD-L1/B7-H1 of total monocytes. A negative correlation is observed in patients with malignant melanoma when measuring surface expression of HLA-DR and PD-LI (E). Box and whisker plots: horizontal line, median; box, 25th and 75th percentiles; whiskers, min and max; **, P < 0.01. Rahul Chavan et al. Cancer Immunol Res 2014;2:241-248 ©2014 by American Association for Cancer Research