Role of fibrillin-1 genetic mutations and polymorphism in aortic dilatation in patients undergoing intracardiac repair of tetralogy of Fallot Ujjwal.

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Presentation transcript:

Role of fibrillin-1 genetic mutations and polymorphism in aortic dilatation in patients undergoing intracardiac repair of tetralogy of Fallot Ujjwal K. Chowdhury, MCh, Diplomate NB, Anand K. Mishra, MCh, Prahlad Balakrishnan, MSc, Sonika Sharma, MSc, Madhulika Kabra, MD, Ruma Ray, MD, MRC (Path), Mani Kalaivani, MSc (Biostatistics), Ruchika Gupta, MD (Path), Raghu M. Govindappa, MS, Ganapathy K. Subramaniam, MCh The Journal of Thoracic and Cardiovascular Surgery Volume 136, Issue 3, Pages 757-766.e10 (September 2008) DOI: 10.1016/j.jtcvs.2007.12.044 Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 ROC of the study group to compare the tradeoffs between the true-positive rate and the false-positive rate of low lamellar count. A lamellar count of 55 as the optimal cutoff point for aortic dilatation in patients undergoing intracardiac repair with a sensitivity of 78.4% and specificity of 73.9%. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 757-766.e10DOI: (10.1016/j.jtcvs.2007.12.044) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 A, SSCP gel picture of exon 24. B, SSCP gel picture of exon 25. C, SSCP gel picture of exon 26. D, SSCP gel picture of exon 27. E, SSCP gel picture of exon 28. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 757-766.e10DOI: (10.1016/j.jtcvs.2007.12.044) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions