Effect of TLR-4 ligation with LPS on NF-κB activation in EOC cells: (A) MyD88+ and (B) MyD88− EOC cells were treated with 10 μg/mL LPS for 1, 2, and 4.

Slides:

Advertisements

Similar presentations

Fig. 9. Treatment of flagellin increased cell survival in hypoxic conditions. (A) After 2 h OGD, cell cytotoxicity levels were measured by a LDH assay.

Advertisements

Enhanced DNA damage in IDH1 mutant glioma cells.

Innate immune-signaling cascades and evidence for upregulation in brain following AIE exposure. Innate immune-signaling cascades and evidence for upregulation.

Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor α expression by inducing.

Dihydromyricetin decreases the sphere formation through downregulation of Sox2 in human osteosarcoma. Dihydromyricetin decreases the sphere formation through.

MD-2s fails to mediate LPS-dependent NF-κB activation and IL-8 secretion. MD-2s fails to mediate LPS-dependent NF-κB activation and IL-8 secretion. A,

S534 phosphorylation affects DNA binding and gene expression by NF-κB at late time points through regulation of p65 stability. S534 phosphorylation affects.

Cetuximab treatment increases IFNγ receptor 1 expression.

Comparison of cytokine profiles induced by ChiLob 7/4 and TLR ligands in ex vivo whole-blood stimulation assays. Comparison of cytokine profiles induced.

Nuclear export of endogenous APC in different cell lines.

BIRC6 is expressed in the tumorigenic Aldefluorhigh fraction of colonosphere cells. BIRC6 is expressed in the tumorigenic Aldefluorhigh fraction of colonosphere.

Maria C. Lebre, Angelic M. G. van der Aar, Lisa van Baarsen, Toni M. M

Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor κB activation in mouse colonocytes Greg C. Kaiser, Fang Yan, D.Brent Polk

Biological validation of the abnormal dynein IC2-GR-COX1 network in NF1-KD PC12 cells identified by integrated proteomics. Biological validation of the.

Fig. 6 DMF inhibits NF-κB translocation upon infection.

Treatment with MI-773 causes changes in p53 status.

Thiocolchicoside inhibits TNF-dependent IκBα phosphorylation, IκBα degradation, p65 phosphorylation, and p65 nuclear translocation. Thiocolchicoside inhibits.

Fig. 2 Role of TLR9 in macrophage activation.

Knocking down Wnt3 increases the cells' response to trastuzumab and reduces cells' invasiveness. Knocking down Wnt3 increases the cells' response to trastuzumab.

RXRa serves as a carrier for TR3 translocation initiated by 9-cis retinoic acid. RXRa serves as a carrier for TR3 translocation initiated by 9-cis retinoic.

Suggested model of integrated regulation of CCL2 by miRNAs and TFs in human adipocytes and macrophages. Suggested model of integrated regulation of CCL2.

The Akt-GSK3β and canonical NF-κB pathways are activated in Slc7a5-deficient osteoclasts. The Akt-GSK3β and canonical NF-κB pathways are activated in Slc7a5-deficient.

The sesquiterpene lactone PN up-regulates MDM2 and p53 proteins.

TFAP2A interacts with HIF-1α and regulates VEGF expression and cell proliferation. TFAP2A interacts with HIF-1α and regulates VEGF expression and cell.

Representative Western blot analyses of S-phase and other proteins from PC3 cell lysates obtained 3 days after oligomer (400 nm)/Lipofectin (15 μg/ml)

Gramicidin A (GA) decreases HIF protein expression in RCC cells.

CDCP1 is required for invadopodia formation and ECM degradation by human breast cancer cells. CDCP1 is required for invadopodia formation and ECM degradation.

Silencing hOGG1 triggers caspase-3 and caspase-7 activation in response to H2O2 in GM00637 cells. Silencing hOGG1 triggers caspase-3 and caspase-7 activation.

Dietary plant extracts inhibit NF-κB activation in vitro.

NF-κB superrepressor was overexpressed by means of the bicistronic retrovirus. NF-κB superrepressor was overexpressed by means of the bicistronic retrovirus.

BME treatment increases granzyme B expression in NK 3.3 cells.

Inhibitory effects of nobiletin and resveratrol on LPS/IFN-γ-induced NO generation in RAW cells. Inhibitory effects of nobiletin and resveratrol.

pDCs from the melanoma environment responded to TLR-L stimulation.

Effects of visfatin on the cell proliferation and phosphorylation of ERK, Akt, and GSK-3β proteins in HCC cells. Effects of visfatin on the cell proliferation.

A, one-step viral growth curves: RT treatment increased the virus yield in MV-CEA–treated U87 cells by up to 2 log as compared with MV-CEA infection only.

A, TSG-6 staining in TRAMP tissue and TRAMP cell lines.

Expression of CRC stem cell markers and L1 in CRC cells.

Curcumin suppresses the expression of antiapoptotic proteins in multiple myeloma cells. Curcumin suppresses the expression of antiapoptotic proteins in.

A. A. Honokiol inhibits TNF-induced NF-κB activation, IκBα phosphorylation, and IκBα degradation. Honokiol inhibits TNF-induced activation of NF-κB. H1299.

Biological effects of BRAF silencing: growth curves of A375 (A) and ARO (B) cell lines in the absence or presence of doxycycline. Biological effects of.

Expression pattern of TLR-4 and MyD88 in EOC cells.

FACS analyses of the inhibitory effect induced by mixed docetaxel, gefitinib, and cyclopamine on EGF plus SHHNp–stimulated PC3 cells. FACS analyses of.

COX-2, Oct-4, and ALDH-1 expression in the mammary gland.

Schematic representation of the interrelationship between monocyte differentiation, NF-κB accumulation and translocation, and TNF-α secretion. Schematic.

Localization of oxidated thiols in A375 melanoma cells.

SBC-5 miR-335+, but not SBC-5 miR-29a+, exhibited reduced IGF-IR expression. SBC-5 miR-335+, but not SBC-5 miR-29a+, exhibited reduced IGF-IR expression.

Effects of HDAC2 inactivation on the invasive potential of human gastric cancer cells. Effects of HDAC2 inactivation on the invasive potential of human.

The effects of HDAC2 knockdown on cell-cycle proteins.

Expression of the cell death markers activated caspase-3 and LC3 I/II in TUBO cells. Expression of the cell death markers activated caspase-3 and LC3 I/II.

Characterization of DNA-PK and PARP-1 levels and activities in the cell lines studied. Characterization of DNA-PK and PARP-1 levels and activities in the.

Met is expressed in Her2-overexpressing cell lines and Her2 (+) breast tumors. Met is expressed in Her2-overexpressing cell lines and Her2 (+) breast tumors.

Schematic workflow of FOXO3 protein separation, proteomic analysis, and O-GlcNAc-modified site identification. Schematic workflow of FOXO3 protein separation,

Host pattern recognition receptors involved in sensing S. pneumoniae.

Osteoactivin expression is required for the invasive phenotype of in vivo selected bone metastatic 4T1 breast cancer cells. Osteoactivin expression is.

Combined inhibition of coamplified RTKs is required for response.

Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Expression.

Monocytes from melanoma patients are unresponsive to TLR3 agonists.

AS1411 alters subcellular distribution of PRMT5 in a time-dependent, dose-dependent, and nucleolin-dependent manner. AS1411 alters subcellular distribution.

CHL-induced apoptosis in HCT116 cells involves the activation of procaspase-8 and procaspase-6, with cleavage of nuclear lamins. CHL-induced apoptosis.

Wnt5A decreases ROR1 expression through proteasomal degradation.

Microbial sensors and responders in colorectal cancer.

BEZ235 induces accelerated senescence after radiation (IR) in vitro.

Establishment of HeLa/rtTAA/TRE-N1-IC cell line.

Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105. Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105.

Effect of SFN on the total activity and protein expression of HDACs in JB6 P+ cells. Effect of SFN on the total activity and protein expression of HDACs.

Effects of NMT siRNAs on MARCKS and c-Src.

miR-181a knockdown inhibits VEGF and MMP1 secretion in vitro.

Knockdown of ROR1 increases the invasive potential of melanoma cells in vitro and in vivo. Knockdown of ROR1 increases the invasive potential of melanoma.

TCTP enhances the protein stability of Pim-3 by blocking the ubiquitin–proteasome degradation of Pim-3. TCTP enhances the protein stability of Pim-3 by.

Toll-like receptors, adapter proteins, and signaling molecules.

Presentation transcript:

Effect of TLR-4 ligation with LPS on NF-κB activation in EOC cells: (A) MyD88+ and (B) MyD88− EOC cells were treated with 10 μg/mL LPS for 1, 2, and 4 hours, and the nuclear and cytoplasmic fractions were separated as described in Materials and Methods. Effect of TLR-4 ligation with LPS on NF-κB activation in EOC cells: (A) MyD88+ and (B) MyD88− EOC cells were treated with 10 μg/mL LPS for 1, 2, and 4 hours, and the nuclear and cytoplasmic fractions were separated as described in Materials and Methods. The translocation of p65 from the cytoplasm into the nucleus was determined by Western blot analyses. Topoisomerase was included to show integrity of the fractions. C, levels of IκB-α in MyD88+ and MyD88− EOC cells following LPS stimulation. Note the decrease in IκB expression in MyD88+ cells but not in MyD88− EOC cells. Results from R182 (MyD88+) and A2780 (MyD88−). Similar results were obtained from other EOC cell lines. Michael G. Kelly et al. Cancer Res 2006;66:3859-3868 ©2006 by American Association for Cancer Research