Figure 3. Multiply-budding yeast-like cells of Blastomyces helicus in calcofluor white stain of bronchoalveolar fluid ... Figure 3. Multiply-budding yeast-like.

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Figure 3. Multiply-budding yeast-like cells of Blastomyces helicus in calcofluor white stain of bronchoalveolar fluid ... Figure 3. Multiply-budding yeast-like cells of Blastomyces helicus in calcofluor white stain of bronchoalveolar fluid (A) and in gram stain of growth from a positive blood culture bottle (case h8) (B). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Clin Infect Dis, Volume 68, Issue 2, 07 June 2018, Pages 188–195, https://doi.org/10.1093/cid/ciy483 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2. Chest radiography findings of 3 patients with pulmonary disease caused by Blastomyces helicus. A, Chest x-ray ... Figure 2. Chest radiography findings of 3 patients with pulmonary disease caused by Blastomyces helicus. A, Chest x-ray demonstrating diffuse nodules (case h8). B, Axial view of computed tomography (CT) of chest showing diffuse nodules and bilateral apical consolidation with cavitation (case h9). C, Axial view of CT of chest showing diffuse ground glass opacities, peribronchovascular nodules, and pleural effusions (case h5, from [15]). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Clin Infect Dis, Volume 68, Issue 2, 07 June 2018, Pages 188–195, https://doi.org/10.1093/cid/ciy483 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 4. (A-D) Morphological features of Blastomyces helicus in culture. A, Colonies showing mold to yeast transition ... Figure 4. (A-D) Morphological features of Blastomyces helicus in culture. A, Colonies showing mold to yeast transition on potato dextrose agar after 13 days at 35°C (case v1 isolate). B-C. Yeast-like phase at 35°C showing multiply-budding yeast-like cells proliferating in short branched chains (case h4 and h1 isolates, respectively). D, Mycelial phase at 25°C showing typical helically coiled hyphae and absence of conidia (case h2 isolate). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Clin Infect Dis, Volume 68, Issue 2, 07 June 2018, Pages 188–195, https://doi.org/10.1093/cid/ciy483 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 1. Geographic origins of human and veterinary Blastomyces helicus isolates, juxtaposed with areas classically ... Figure 1. Geographic origins of human and veterinary Blastomyces helicus isolates, juxtaposed with areas classically considered endemic for B. dermatitidis (modified from [17] based on [18–21]). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Clin Infect Dis, Volume 68, Issue 2, 07 June 2018, Pages 188–195, https://doi.org/10.1093/cid/ciy483 The content of this slide may be subject to copyright: please see the slide notes for details.