PP2A fulfills its promises as tumor suppressor

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PP2A fulfills its promises as tumor suppressor Christine Van Hoof, Jozef Goris Cancer Cell Volume 5, Issue 2, Pages 105-106 (February 2004) DOI: 10.1016/S1535-6108(04)00027-3

Figure 1 Schematic representation of PP2A-ST interaction Small t interaction with PP2A displaces the B′/B56/PR61γ regulatory subunit, leading to an increased phosphorylation of specific PP2A-B′/B56/PR61γ substrates. This results in an increased cell proliferation and anchorage-independent growth, leading to tumor formation. Cancer Cell 2004 5, 105-106DOI: (10.1016/S1535-6108(04)00027-3)