The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. A,

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The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. A, IAA suppresses growth of SK-MEL-2, 5, 28, and WM-266-4 human melanoma cells. Proliferation levels were measured by MTT assay. The asterisks indicate significant differences between treated groups and untreated controls (**, P < 0.01; ***, P < 0.001). B, IAA inhibits anchorage-independent growth of SK-MEL-28 cells (a, untreated control; b, 10 μmol/L IAA; c, 20 μmol/L IAA). Glycyrrhizin has no effect on anchorage-independent growth of SK-MEL-28 cells (d, untreated control; e, 10 μmol/L glycyrrhizin; f, 20 μmol/L glycyrrhizin). Data are presented as mean ± SD of the number of colonies determined from three independent experiments. The asterisks indicate a significant (**, P < 0.01; ***, P < 0.001) decrease in the number of colonies after treatment with IAA versus untreated control group. Nu Ry Song et al. Cancer Prev Res 2013;6:1293-1303 ©2013 by American Association for Cancer Research