Lesion mapping in LBD patients.

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Lesion mapping in LBD patients. Lesion mapping in LBD patients. A, Overlays of regional lesion plots of the 21 patients with limb apraxia and gesture recognition deficit (LA+(LBD)) and of the 12 patients without limb apraxia (LA−(LBD)). Legend, The number of overlapping lesions is illustrated by different colors that code for increasing frequencies from violet (lesion in one patient) to red (lesion in all the patients of the respective group). B, Subtraction image of lesions in patients without limb apraxia from those with limb apraxia [(LA+(LBD)) − (LA−(LBD))]. Left, Axial views are in the left part. Right, Coronal views and sagittal renderings. Legend, Lesion subtractions show the highest difference in lesion density illustrated by different colors that code for increasing frequencies from dark red to yellow (positive values) and from dark blue to light blue (negative values). Each color represents a 20% increment. Positive and negative values indicate regions damaged more frequently in patients with or without limb apraxia, respectively. The images show that limb apraxia is associated with frontoparietal lesions. Mariella Pazzaglia et al. J. Neurosci. 2008;28:3030-3041 ©2008 by Society for Neuroscience