Effects of CNO on spontaneous locomotion and amphetamine-induced hyperlocomotion. Effects of CNO on spontaneous locomotion and amphetamine-induced hyperlocomotion.

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Effects of CNO on spontaneous locomotion and amphetamine-induced hyperlocomotion. Effects of CNO on spontaneous locomotion and amphetamine-induced hyperlocomotion. Rats were pretreated with either vehicle or CNO, followed 20 min later by either vehicle or amphetamine. A–F, CNO at 1 mg/kg (A, B), 2 mg/kg (C, D), or 5 mg/kg (E, F) had no effect on spontaneous locomotion. Neither 1 nor 2 mg/kg CNO altered amphetamine-induced hyperlocomotion (B, D), but 5 mg/kg CNO significantly reduced the effects of amphetamine (F). *p < 0.05, **p < 0.01. Duncan A. A. MacLaren et al. eneuro 2016;3:ENEURO.0219-16.2016 ©2016 by Society for Neuroscience