Cryopreserved CD34+ Cell Dose, but Not Total Nucleated Cell Dose, Influences Hematopoietic Recovery and Extensive Chronic Graft-versus-Host Disease after.

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Cryopreserved CD34+ Cell Dose, but Not Total Nucleated Cell Dose, Influences Hematopoietic Recovery and Extensive Chronic Graft-versus-Host Disease after Single- Unit Cord Blood Transplantation in Adult Patients Takaaki Konuma, Seiko Kato, Maki Oiwa-Monna, Susumu Tanoue, Miho Ogawa, Masamichi Isobe, Arinobu Tojo, Satoshi Takahashi Biology of Blood and Marrow Transplantation Volume 23, Issue 7, Pages 1142-1150 (July 2017) DOI: 10.1016/j.bbmt.2017.03.036 Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Correlation between time to hematopoietic recovery and each cryopreserved cell dose based on actual and ideal body weight among patients who achieved hematopoietic engraftment. (A) Correlation between neutrophil engraftment and TNC dose. (B) Correlation between neutrophil engraftment and CD34+ cell dose. (C) Correlation between neutrophil engraftment and CFU-GM dose. (D) Correlation between platelet engraftment and TNC dose. (E) Correlation between platelet engraftment and CD34+ cell dose. (F) Correlation between platelet engraftment and CFU-GM dose. (G) Correlation between RBC engraftment and TNC dose. (H) Correlation between RBC engraftment and CD34+ cell dose. (I) Correlation between RBC engraftment and CFU-GM dose. Biology of Blood and Marrow Transplantation 2017 23, 1142-1150DOI: (10.1016/j.bbmt.2017.03.036) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 The cumulative incidences of neutrophil engraftment after CBT. The cumulative incidences of neutrophil engraftment after CBT according to TNC dose based on ABW (A) and IBW (B), CD34+ cell dose based on ABW (C) and IBW (D), and CFU-GM dose based on ABW (E) and IBW (F). Biology of Blood and Marrow Transplantation 2017 23, 1142-1150DOI: (10.1016/j.bbmt.2017.03.036) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 The cumulative incidences of extensive chronic GVHD after CBT. The cumulative incidences of extensive chronic GVHD after CBT according to TNC dose based on ABW (A) and IBW (B), CD34+ cell dose based on ABW (C) and IBW (D), and CFU-GM dose based on ABW (E) and IBW (F). Biology of Blood and Marrow Transplantation 2017 23, 1142-1150DOI: (10.1016/j.bbmt.2017.03.036) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions