Reconstitution of RhoH expression in HCL inhibits homotypic adhesion.

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Reconstitution of RhoH expression in HCL inhibits homotypic adhesion. Reconstitution of RhoH expression in HCL inhibits homotypic adhesion. A, light microscope images of JOK-1 cells that contain in their genome either pMEP4 (Empty) or pMEP-RhoH (RhoH). Cells were photographed 3 d after a culture of single cells was initiated in the absence of supplementary CdCl2. B, the percentage of cells not present in an aggregate of two or more. These values were calculated each day for 3 d after single-cell cultures were initiated from 0.5 × 106 JOK-1 cells that stably express either pMEP4 or pMEP-RhoH. Columns, mean of 10 microscopic fields of 1 mm2 of two independent experiments; bars, SE. C, the percentage of cells present in aggregates classified as small (S; 0.1–0.25 × 0.01 mm2), medium (M; 0.5–1.0 × 0.01 mm2), or large (L; 1.5–20.0 × 0.01 mm2). These values were calculated each day for 3 d after single-cell cultures were initiated. Columns, mean of six microscope fields of 1 mm2 of two independent experiments; bars, SE. Asterisks denote values of 0%. Sylvie Galiègue-Zouitina et al. Cancer Res 2008;68:4531-4540 ©2008 by American Association for Cancer Research