Oncoprotein synthesis and mechanism of action of omacetaxine mepesuccinate. Oncoprotein synthesis and mechanism of action of omacetaxine mepesuccinate.

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Oncoprotein synthesis and mechanism of action of omacetaxine mepesuccinate. Oncoprotein synthesis and mechanism of action of omacetaxine mepesuccinate. A, oncogenes are transcribed to mRNAs followed by protein synthesis on ribosomes to produce oncoproteins such as Bcr-Abl, Mcl-1, and Myc. B, oncogenes are transcribed but protein synthesis on ribosomes is blocked by action of omacetaxine. This results in overall inhibition of protein synthesis. Proteins with short half-lives, such as Bcr-Abl, Mcl-1, and Myc, diminish. If cells are dependent on these proteins for survival, they undergo apoptosis. Varsha Gandhi et al. Clin Cancer Res 2014;20:1735-1740 ©2014 by American Association for Cancer Research