Constitutive characteristics in HL-mice and HL-HPS-mice. Constitutive characteristics in HL-mice and HL-HPS-mice. A, macroscopic characteristics of HL-mice (left) and HL-HPS-mice (right) are presented. B, L*-values (mean ± SD) evaluated by using a reflectance spectrophotometer in HL-mice and HL-HPS-mice are presented. Pigmented skin in HL-HPS-mice was confirmed by digital data. C, constitutive urinary 8-OHdG levels (mean ± SD) in HL-mice and HL-HPS-mice are presented. **, significantly different (P < 0.01) from the control by the Mann–Whitney U test. Masashi Kato et al. Cancer Epidemiol Biomarkers Prev 2011;20:1622-1628 ©2011 by American Association for Cancer Research