Identification of molecular subtypes of leiomyosarcoma (LMS) in the TCGA data. Identification of molecular subtypes of leiomyosarcoma (LMS) in the TCGA.

Slides:

Advertisements

Similar presentations

Advertisements

Key For All Figures CYAN NODE = DBF ORANGE = PRO BROWN = Gov’t YELLOW = Pharma GRAY = VC WHITE = Other Triangle = New Entrant Circle = Incumbent Node size.

Rearrangements of Gene A and Gene B

PLGEM fits equally well on NSAF and GeneChip datasets

Immunity-related genes and enhancers are enriched for eQTLs.

Frequency of JAK1 and JAK2 alterations and their association with overall survival in TCGA datasets. Frequency of JAK1 and JAK2 alterations and their association.

Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors Michael Dannemann, Aida M.

Effect of dorsal rhizotomy on CaV2

Volume 23, Issue 11, Pages (June 2018)

Representative multiplex immunofluorescence image of synovial sarcoma with increased PD-L1/PD-1/CD8 cell densities at the tumor-invasive margin demonstrating.

PCA of RNAseq data from CTL TB and EOPE TB (GSE119265).

What Color is it?.

Obesity and type 2 diabetes forecasts.

Observed (symbols) and model predicted (lines) dopamine time courses in rats following D-amphetamine administration. Observed (symbols) and model predicted.

Relative quantitation of phosphopeptides from conditioned media from subtype specific breast cancer cell lines. Relative quantitation of phosphopeptides.

The BRD4 bromodomain is critical for expression of SASP genes.

Robustness of TRU, Proximal-proliferative (PP), and Proximal-inflammatory (PI) classification. Robustness of TRU, Proximal-proliferative (PP), and Proximal-inflammatory.

Differential protein, mRNA, lncRNA and miRNA regulation by p53.

RNA-Seq analysis of CYR1 cells in the adaptation to acid pH.

Effect on immune response following B. lactis administration.

Differences in Verrucomicrobia genera across plant community types.

Whole-genome microarray analysis of gene expression in the livers of control mice and STAM mice subjected to NASH-derived hepatocarcinogenesis. Whole-genome.

Fig. 1 Study area and field site setting.

Fig. 4 Visualization of the 20 occipital lobe models, trained to predict EmoNet categories from brain responses to emotional images. Visualization of the.

Transcriptomic changes in strains PAK and PAKpmrB6 in response to polymyxin B (PMB). Transcriptomic changes in strains PAK and PAKpmrB6 in response to.

Top: probability distribution of the mass-to-light ratios observed when nebular emission is included in the fitting, stacked across all of the MC samples.

A, Top inhibitors of Ba/F3 transformed with CD74–ROS1, color coded by clinical development status: FDA-approved (green), phase III (yellow), phase II (blue),

Association between RB pathway alterations and poor prognosis in early-stage lung adenocarcinoma patients. Association between RB pathway alterations and.

X-tile analysis of survival data from the SEER registry reveals a continuous distribution based on tumor size and node number, and a U-shaped distribution.

Landscape of the TME in gastric cancer and characteristics of TME subtypes. Landscape of the TME in gastric cancer and characteristics of TME subtypes.

Immune signatures of patients with short-, medium-, and long-term survival. Immune signatures of patients with short-, medium-, and long-term survival.

CLL-1 expression in patients with AML and normal donors.

M-Wnt and E-Wnt cells cluster tightly with claudin-low and basal-like breast tumors, respectively, by microarray analysis. M-Wnt and E-Wnt cells cluster.

Personalized, 16-plex assays accurately detect ctDNA ahead of clinical relapse. Personalized, 16-plex assays accurately detect ctDNA ahead of clinical.

A, unsupervised clustering of all BRCA1 (red), BRCA2 (blue), and sporadic (green) breast tumors of our collection using the regions reported as discriminative.

Molecular signatures are independent of tumor stage and grade.

PAP- and PA2024-specific CTLs at week 0 (prior to sipuleucel-T infusion) and at weeks 6 and 26 post–sipuleucel-T treatment. PAP- and PA2024-specific CTLs.

Kaplan-Meier survival analysis of p53 mutation in the overall breast tumor series. Kaplan-Meier survival analysis of p53 mutation in the overall breast.

Fig. 4 Relationships between light and economic parameters.

A, Stacked Venn plots of the significantly associated (FDR < 25%) KEGG pathways for 3 imaging subtypes with GSEA. B, Pathway activity scores for 3 imaging.

Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors Michael Dannemann, Aida M.

Phenotypic diversity of individual multiple myeloma clones.

PD-1 expression in ovarian cancer.

Correlations of the breast cancer hypoxia metagene with Ki67 and the proliferation metagene. Correlations of the breast cancer hypoxia metagene with Ki67.

Convergent expansion in less predominant B-lineage clones.

Pancreatic adenocarcinoma, chronic pancreatitis, and normal pancreas samples can be distinguished on the basis of gene expression profiling. Pancreatic.

One-way hierarchical cluster analysis of SAM-identified genes using the TMEV software to see the data substructure. One-way hierarchical cluster analysis.

High-risk neuroblastoma molecular subtypes classification and inference of master regulators. High-risk neuroblastoma molecular subtypes classification.

Location of the ER mutations and frequencies per cohort.

Kaplan–Meier curves for RFS and OS by various marker groups.

Untargeted LC/MS metabolite profiling of DFMO-treated HT-29 colorectal cancer cells. Untargeted LC/MS metabolite profiling of DFMO-treated HT-29 colorectal.

A and B, two blocks from the original specimen used for TMA demonstrated areas with varying patterns of ALK rearrangement and KRAS mutation status. A and.

Gene expression patterns of SLC and ABC transporters in normal and tumor tissues. Gene expression patterns of SLC and ABC transporters in normal and tumor.

Mean percentage change from baseline in total IGF-I and the R1507 serum concentration values following a single i.v. administration of R mg/kg (n.

Unsupervised principal-component analysis (PCA) of 129 seroreactive antigens for adults and children from different geographical locations. Unsupervised.

ROC analysis of MIC-1 and CA19-9.

Frequently mutated genes in colorectal cancer.

Global mutational landscape of the 170 lung adenocarcinoma patients (discovery cohort). Global mutational landscape of the 170 lung adenocarcinoma patients.

Molecular definitions of lung adenocarcinoma subtypes.

Identification of putative TET1 targets in TNBC

Correlations between APOBEC expression and immune cell markers across 22 cancer types. Correlations between APOBEC expression and immune cell markers across.

EZH2-driven lung cancer as a molecularly distinct entity.

Gene expression heatmap of non–T-cell-inflamed, intermediate, and T-cell–inflamed testicular germ cell tumors from TCGA. Genes are on the row, and samples.

TME characteristics of TCGA-STAD subtype and cancer somatic genome.

Fig. 2 Spatial distribution of five city groups.

Transcriptome profiling of PD-L1 antibody–treated macrophages showed inflammatory phenotype, increased survival and proliferation, and decreased apoptosis.

Fig. 1 Epigenomic and genomic variations between dwarf and normal whitefish species and their reciprocal hybrids. Epigenomic and genomic variations between.

Relative risks are plotted at the midpoints of the three time periods.

Presentation transcript:

Identification of molecular subtypes of leiomyosarcoma (LMS) in the TCGA data. Identification of molecular subtypes of leiomyosarcoma (LMS) in the TCGA data. A, empirical cumulative distribution plots as a function of the number of molecular subtypes in TCGA cohort. B, consensus clustering matrix of leiomyosarcoma samples using 3 molecular subtypes. C, subclass association (SA) matrix between 3SEQ data (subtype I, subtype II, subtype III) and TCGA data (subtype C1, subtype C2, subtype C3). P value is corrected with FDR. D, principal component analysis (PCA) of 70 core 3SEQ leiomyosarcoma cases with other diagnoses. Subtype I leiomyosarcoma, black circle; subtype II leiomyosarcoma, red triangle; subtype III leiomyosarcoma, green triangle; leiomyoma, cyan solid circle; myometrium, orange solid circle; undifferentiated pleomorphic sarcomas, blue solid pyramid. The elliptical contours represent the normal probability of 0.75. Xiangqian Guo et al. Clin Cancer Res 2015;21:3501-3511 ©2015 by American Association for Cancer Research