Schematic description of sites of action of different antifungal agents. Schematic description of sites of action of different antifungal agents. Candins.

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Sites of action of antifungal drugs

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Schematic description of sites of action of different antifungal agents. Schematic description of sites of action of different antifungal agents. Candins cause disruption of cell wall, allowing other antifungals (polyenes, azoles, and 5-FC) to enter. Azoles and polyenes can inhibit or bind to ergosterol, leading to cell lysis and allowing 5FC to enter the cell and inhibit nucleic acid synthesis. Dashed arrows indicate the site of action for each antifungal class. The mechanisms of action for each class of antifungal agent are depicted in panels A through D. Pranab K. Mukherjee et al. Clin. Microbiol. Rev. 2005; doi:10.1128/CMR.18.1.163-194.2005