Contrast agent uptake for the four different groups of MMA mice

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Fig. 2 Contrast agent uptake for the four different groups of MMA mice. Contrast agent uptake for the four different groups of MMA mice. (A) Average iopamidol uptake with time for RD Mut+/− and RD Mut−/− mice. RD Mut+/− mice display higher uptake of contrast agent [>25% (n = 5)] than RD Mut−/− mice [>12% (n = 4)]. (B) Average iopamidol uptake with time for HP Mut+/− and HP Mut−/− mice. Similar to RD Mut+/− mice, >25% contrast was observed for HP Mut+/− mice. HP Mut−/− mice displayed the lowest contrast [~4% (n = 3)], indicating the lowest iopamidol uptake for these mice with more advanced kidney disease. (C and D) Corresponding time-averaged maximum contrast images of RD Mut+/− and RD Mut−/− mice. (E and F) Maximum contrast images of HP Mut+/− and HP Mut−/− mice. KowsalyaDevi Pavuluri et al. Sci Adv 2019;5:eaaw8357 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).