Sites of sodium reabsorption and diuretic action along the nephron.

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Sites of sodium reabsorption and diuretic action along the nephron. Sites of sodium reabsorption and diuretic action along the nephron. (A) Nephron figure showing percentages of sodium reabsorption by associated segment. (B) Homology structural model of the loop diuretic–sensitive NKCC2 viewed from the extracellular surface. The pocket for ion translocation and diuretic binding is shown by the arrow. Mutation of a key phenylalanine (F372) alters diuretic binding (reconstruction adapted from Somasekharan et al. [2]). Aldo, aldosterone; Aml, amiloride (and triamterene); CAI, carbonic anhydrase inhibitors; DCTD, distal convoluted tubule diuretic; LD, loop diuretics; MR, mineralocorticoid receptor, site of spironolactone and eplerenone action (not shown). David H. Ellison CJASN doi:10.2215/CJN.09630818 ©2019 by American Society of Nephrology