Ivan Topisirovic, Nahum Sonenberg Cell

Slides:

Advertisements

Similar presentations

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.

Local Translation of Extranuclear Lamin B Promotes Axon Maintenance Byung C. Yoon, Hosung Jung, Asha Dwivedy, Catherine M. O'Hare, Krishna H. Zivraj, Christine.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Transcriptional Control of Gene Expression by MicroRNAs Basel Khraiwesh, M. Asif Arif, Gotelinde I. Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski,

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

Dynein Anchors Its mRNA Cargo after Apical Transport in the Drosophila Blastoderm Embryo Renald Delanoue, Ilan Davis Cell Volume 122, Issue 1, Pages

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming Smita Srivastava, Joel D. Ernst Cell Host & Microbe Volume 15, Issue 6,

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model Jennifer S. Pfingsten, Karen J. Goodrich, Cornelius Taabazuing,

Protein Accounting in the Cellular Economy

Liver Transplantation: From Inception to Clinical Practice

A Pro-metastatic tRNA Pathway

CoSMoS Unravels Mysteries of Transcription Initiation

Unweaving the Autism Spectrum

Linking Protein and RNA Function within the Same Gene

Mapping Human Epigenomes

Should I Stay or Should I Go: Neuromodulators of Behavioral States

Aminoacylation of Proteins: New Targets for the Old ARSenal

In This Issue Cell Volume 158, Issue 5, (August 2014)

Volume 131, Issue 1, Pages (October 2007)

Protein Accounting in the Cellular Economy

How the Sequence of a Gene Can Tune Its Translation

Aminoacylation of Proteins: New Targets for the Old ARSenal

Volume 152, Issue 1, (January 2013)

Trapping the Ribosome to Control Gene Expression

Volume 175, Issue 1, Pages 6-9 (September 2018)

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Translational Control by the Eukaryotic Ribosome

The Ribosome Emerges from a Black Box

Volume 130, Issue 6, (September 2007)

Phytochromes: Where to Start?

Modeling Transcriptome Dynamics in a Complex World

MicroRNAs in a Cardiac Loop: Progenitor or Myocyte?

A Lifelong Passion for All Things Ribonucleic

Modifications on Translation Initiation

Division of Labor: Minor Splicing in the Cytoplasm

Easy Stress Relief by EZH2

A Penetrating Look at Stochasticity in Development

Competition by the Masses

Volume 143, Issue 6, (December 2010)

Regulatory RNAs in Bacteria

RNA Quality Control in Eukaryotes

Making the Most from Changes in Life

The Cell Biology of Genomes: Bringing the Double Helix to Life

Volume 165, Issue 2, Pages (April 2016)

RNA Methylation Clears the Way

Joel D. Richter, Jeff Coller Cell

Learning from the Uncontrollable

Volume 163, Issue 4, (November 2015)

A Relay Race on the Evolutionary Adaptation Spectrum

Volume 163, Issue 2, (October 2015)

Volume 134, Issue 6, (September 2008)

Dynamic RNA Modifications in Posttranscriptional Regulation

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

Targeting Protein Stability with a Small Molecule

Kevin Huang, Guoping Fan Cell Stem Cell

Presentation transcript:

Distinctive tRNA Repertoires in Proliferating versus Differentiating Cells Ivan Topisirovic, Nahum Sonenberg Cell Volume 158, Issue 6, Pages 1238-1239 (September 2014) DOI: 10.1016/j.cell.2014.08.031 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Transfer RNA Pools Are Coordinated with the Alterations in the Transcriptome Optimal differentiation (red) and proliferation (green) require distinct changes in the transcriptome. The repertoire of tRNAs in differentiating cells (red) is opposite to that observed in proliferating cells (green). This appears to be a consequence of changes in transcription of tRNA genes caused by specific epigenetic modifications (red and green circles). During differentiation, tRNAs that increase in the abundance (red) harbor anticodons that are optimal for translation of codons found in differentiation-promoting mRNAs (red), whereas tRNAs that are elevated during proliferation (green) are tuned for the optimal codon usage of proliferation-promoting mRNAs (green). Cell 2014 158, 1238-1239DOI: (10.1016/j.cell.2014.08.031) Copyright © 2014 Elsevier Inc. Terms and Conditions