Regional association plot of genotyped and imputed SNPs in proximity to rs2687201, summarizing evidence of interaction with at least weekly heartburn or.

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Regional association plot of genotyped and imputed SNPs in proximity to rs2687201, summarizing evidence of interaction with at least weekly heartburn or reflux in relation to risk of Barrett's esophagus. Regional association plot of genotyped and imputed SNPs in proximity to rs2687201, summarizing evidence of interaction with at least weekly heartburn or reflux in relation to risk of Barrett's esophagus. The top portion of the figure has physical position along the x-axis, and −log10(P value) for the interaction term on the y-axis. Each dot on the plot represents the value of the interaction between a SNP (coded as 0/1) and GERD in relation to Barrett's esophagus risk. The index SNP is marked as a purple square, other genotyped SNPs are marked with squares, and imputed SNPs are marked by circles. The color scheme represents the pairwise correlation (r2) between a given SNP and the index SNP. Correlation was calculated using the HapMap CEU data. Bottom, position of genes across the region. James Y. Dai et al. Cancer Epidemiol Biomarkers Prev 2015;24:1739-1747 ©2015 by American Association for Cancer Research