LY2780301 induces cytotoxicity in hMECs via inhibition of Akt/p70S6K kinase activities. LY2780301 induces cytotoxicity in hMECs via inhibition of Akt/p70S6K.

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Date of download: 7/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Inhibition of the Growth of Papillary Thyroid Carcinoma.

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LY2780301 induces cytotoxicity in hMECs via inhibition of Akt/p70S6K kinase activities. LY2780301 induces cytotoxicity in hMECs via inhibition of Akt/p70S6K kinase activities. A, Cell growth curve of 10A.Vec and 10A.B2 cells treated with LY2780301. DMSO was used as vehicle control. B, Western blotting of PCNA in 10A.Vec and 10A.B2 cells treated with LY2780301 at various dosages. Quantification of PCNA band was shown underneath each lane. C, Flow cytometry dot plot of 10A.Vec and 10A.B2 cells treated with LY2780301 and stained with PI and BrdU-APC for cell-cycle determination. Quantification of each subgroup (G0–G1 phase, S-phase, and G2–M phase) under different treatment conditions was summarized and shown to the right of the plot. Xiao Wang et al. Cancer Prev Res 2017;10:641-650 ©2017 by American Association for Cancer Research