Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: Insight into ischemia-induced reduction in endothelium-dependent.

Slides:

Advertisements

Similar presentations

The additional hospital costs generated in the management of complications of pacemaker and defibrillator implantations T.Bruce Ferguson, MD, Candice Lilley.

Advertisements

Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower.

Clinical evaluation of recombinant human platelet – derived growth factor for the treatment of lower extremity diabetic ulcers David L. Steed, MD, the.

Manuel J. Antunes, MD, PhD, DSc

B. Zane Atkins, MD, Scott C. Silvestry, MD, Ravi N. Samy, MD, Ashish S

Hypercholesterolemia Impairs the Myocardial Angiogenic Response in a Swine Model of Chronic Ischemia: Role of Endostatin and Oxidative Stress Munir Boodhwani,

Altered coronary microvascular serotonin receptor expression after coronary artery bypass grafting with cardiopulmonary bypass Michael P. Robich, MD,

Wei Zhou, MD, Hong Chai, MD, PhD, Peter H. Lin, MD, Alan B

Angiogenic response induced by mechanical transmyocardial revascularization Victor Chu, MDa, Jin-qiang Kuang, MDa, Amy McGinna, Adel Giaid, PhDb, Stephen.

Guo-Wei He, MD, PhD, Cheng-Qin Yang, MD

Neel R. Sodha, MD, Frank W. Sellke, MD

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Comparative Effects of Continuous Warm Blood and Intermittent Cold Blood Cardioplegia on Coronary Reactivity Motohisa Tofukuji, MD, PhD, Alon Stamler,

Centers for Disease Control “increased-risk” organ donor: Not so risky? Francis D. Pagani, MD, PhD The Journal of Thoracic and Cardiovascular Surgery

Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium Michael P. Robich, MD, MSPH, Louis M. Chu, MD,

Basal nitric oxide expresses endogenous cardioprotection during reperfusion by inhibition of neutrophil-mediated damage after surgical revascularization

Nonischemic myocardial acidosis adversely affects microvascular and myocardial function and triggers apoptosis during cardioplegia Kamal R. Khabbaz,

Endogenous myocardial angiogenesis and revascularization using a gastric submucosal patch Marc A Ruel, MD, MPh, Frank W Sellke, MD, Cesario Bianchi,

Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia Ashraf A. Sabe, MD, Brittany.

The use of methylene blue as an extravascular surgical marker impairs vascular responses of human saphenous veins Dustan A. Barber, PhDa, Joseph W. Rubin,

The effect of elevated homocysteine levels on adrenergic vasoconstriction of human resistance arteries: The role of the endothelium and reactive oxygen.

The lord of the rings Antonio Miceli, MD, PhD

Intermittent aortic crossclamping prevents cumulative adenosine triphosphate depletion, ventricular fibrillation, and dysfunction (stunning): Is it preconditioning?

Effect of esophageal distention on pressure and electromyographic activity of the pharyngoesophageal sphincter, with identification of the esophagopharyngeal.

Editorial: The core of leadership

Alcohol and the Heart: A Proteomics Analysis of Pericardium and Myocardium in a Swine Model of Myocardial Ischemia Nassrene Y. Elmadhun, MD, Ahmed A.

Primary repair of rupture of a main and lobar bronchus

Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome Nassrene Y. Elmadhun, MD, Antonio D.

Cardiopulmonary bypass, myocardial management, and support techniques Changes in autonomic response of the cerebral circulation after normothermic extracorporeal.

Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial.

Support Your Specialty

Vascular endothelial growth factor and basic fibroblast growth factor in children with cyanotic congenital heart disease Sandra L. Starnes, MDa, Brian.

A first start for lung transplantation?

Reversal of refractory hypotension with single-dose methylene blue after coronary artery bypass surgery P. Yiu, FRCSa, J. Robin, MRCPb, C.W. Pattison,

Intermediate-Term Outcome Of Mitral Reconstruction In Cardiomyopathy

Cardioplegia and vascular injury

Munir Boodhwani, MD, William E

Tissue concentrations of endothelins and functional effects of endothelin-receptor activation in human arteries and veins Peter Holm, MD, Anders Franco-Cereceda,

Pharmacologic relaxation of vein grafts is beneficial compared with pressure distention caused by upregulation of endothelial nitric oxide synthase and.

Joseph A. Dearani, MD, Michael J. Ackerman, MD, PhD

Endothelium-dependent contraction of canine coronary artery is enhanced by crystalloid cardioplegic solution Pyng Jing Lin, MD, Chau-Hsiung Chang, MD,

Michael Kronon, MD. , Kirk S. Bolling, MD, Bradley S

Attachment disorder in thoracoabdominal surgery

Ara K. Pridjian, MD, Edward L. Bove, MD, Flavian M. Lupinetti, MD

Reviewer Acknowledgment

Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine myocardium M.Salik Jahania,

Sialyl LewisX oligosaccharide preserves cardiopulmonary and endothelial function after hypothermic circulatory arrest in lambs Marc L. Schermerhorn,

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

Preconditioning improves cardioplegia-related coronary microvascular smooth muscle hypercontractility: Role of KATP channels Naruto Matsuda, MD, PhDa,

Subodh Verma, MD, PhDa, Fina Lovren, PhDb, Aaron S

Mesenteric dysfunction after cardiopulmonary bypass: role of complement C5a Motohisa Tofukuji, MD, PhD, Gregory L Stahl, PhD, Caroline Metais, MD, Mikio.

Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pig Motohisa Tofukuji, MD, PhD, Caroline Metais, MD, Charles D Collard,

Simultaneous Antegrade And Retrograde Delivery Of Continuous Warm Blood Cardioplegia After Global Ischemia Anders B. Ericsson, MD, Shigeto Takeshima,

Discussion The Journal of Thoracic and Cardiovascular Surgery

Munir Boodhwani, MD, MMSc, Neel R

Tai Ji: The law of inflammatory response

The future of cardiac surgery training: A survival guide

Atrial natiuretic peptide release at rest and with exercise after cardiac transplantation with bicaval anastomoses Andres W. Jahnke, MD*, Rainer Leyh,

High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine

L-arginine, prostaglandin, and white cell filtration equally improve myocardial protection in stressed neonatal hearts Michael T. Kronon, MD, Bradley.

Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined.

Hypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries Kimihiro Komori, MD, Hiroaki Shimokawa,

Goya V. Raikar, MD, Kunikazu Hisamochi, MD, Bao-Lan N

Nitroglycerin as a nitric oxide donor accelerates lipid peroxidation but preserves ventricular function in a canine model of orthotopic heart transplantation

George D. Lilly 1906–1988 Journal of Vascular Surgery

Loss of endothelium-dependent vasodilatation and nitric oxide release after myocardial protection with University of Wisconsin solution Jeffrey M. Pearl,

Therapeutic Angiogenesis With Basic Fibroblast Growth Factor: Technique and Early Results Frank W Sellke, MD, Roger J Laham, MD, Elazer R Edelman, MD,

Panagiotis Kougias, MD, Hong Chai, MD, PhD, Peter H. Lin, MD, Alan B

Koh Takeuchi, MD, Pedro J. del Nido, MD, Andra E

Efficacy of prostaglandin E1 in the treatment of lower extremity ischemic ulcers secondary to peripheral vascular occlusive disease James J. Schuler,

Presentation transcript:

Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: Insight into ischemia-induced reduction in endothelium-dependent vasodilatation Roger J. Laham, MD, Michael Simons, MD, Motohisa Tofukuji, MD, PhD, David Hung, MD, PhD, Frank W. Sellke, MD The Journal of Thoracic and Cardiovascular Surgery Volume 116, Issue 6, Pages 1022-1028 (December 1998) DOI: 10.1016/S0022-5223(98)70055-8 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Myocardial vascular resistance in the normal (LAD) and collateral-dependent (LCX) territories at 3 weeks. Four weeks after intrapericardial drug delivery, vascular resistance in the collateral-dependent LCX territory was lower in bFGF-treated animals than in control animals. Data are shown as mean ± standard deviation. *Statistical significance (P < .0017) compared with LAD at 3 weeks and LCX final compared with LCX at 3 weeks. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 1022-1028DOI: (10.1016/S0022-5223(98)70055-8) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Endothelium-independent (SNP, A) and endothelium-dependent (ADP, B) vasodilatation in the normal (LAD) myocardium. Responses are expressed as percent relaxation of acetylcholine-induced precontraction. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 1022-1028DOI: (10.1016/S0022-5223(98)70055-8) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Endothelium-independent (SNP, A) and endothelium-dependent (ADP, B) vasodilation in the collateral-dependent LCX myocardium showing preserved response to SNP with impaired response to ADP, restored by bFGF treatment. Responses are expressed as percent relaxation of acetylcholine-induced precontraction. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 1022-1028DOI: (10.1016/S0022-5223(98)70055-8) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 4 Expression of iNOS and eNOS in ischemic and normal myocardium by reverse transcriptase–polymerase chain reaction (RT-PCR) and Western analysis. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 1022-1028DOI: (10.1016/S0022-5223(98)70055-8) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 5 Endothelium-dependent vasodilatation (ADP) was not affected by the presence of 2 different concentrations (10–6 and 10–7 mol/L) of SNP, an NO donor. Responses are expressed as percent relaxation of acetylcholine-induced precontraction. The Journal of Thoracic and Cardiovascular Surgery 1998 116, 1022-1028DOI: (10.1016/S0022-5223(98)70055-8) Copyright © 1998 Mosby, Inc. Terms and Conditions