Immunohistochemistry for phosphorylated (S235) S6 ribosomal protein and quantitation of Ki67 labeling indices in vehicle- and WAY-129327–treated Eker (Tsc2+/−)

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Presentation transcript:

Immunohistochemistry for phosphorylated (S235) S6 ribosomal protein and quantitation of Ki67 labeling indices in vehicle- and WAY-129327–treated Eker (Tsc2+/−) rats. Immunohistochemistry for phosphorylated (S235) S6 ribosomal protein and quantitation of Ki67 labeling indices in vehicle- and WAY-129327–treated Eker (Tsc2+/−) rats. WAY-129327 treatment significantly decreased endometrial phosphorylated (S235) S6 immunoreactivity (B) compared with vehicle-treated controls (A). Immunohistochemistry, ×200. WAY-129327 treatment also significantly reduced the endometrial epithelial Ki67 labeling index (C). Cell proliferation was scored by calculating the percentage of Ki67-positive endometrial epithelial cells per 100 epithelial cells for endometrial hyperplastic lesions from vehicle-treated controls (n = 54 lesions) and from hyperplastic lesions in the WAY-129327–treated rats (n = 6 lesions). Original magnification, ×200. Columns, mean; bars, SE. *, P < 0.05. Adrienne S. McCampbell et al. Cancer Prev Res 2010;3:290-300 ©2010 by American Association for Cancer Research