Week 5: The Action Potential – Part 1

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Presentation transcript:

Week 5: The Action Potential – Part 1 BIOL3833 Week 5: The Action Potential – Part 1

Agenda Today: Thursday: Brief lecture then complete Simulations/HW 1) Quick introduction to this week’s topic: The action potential 2) Finish simulations for HW2, Begin simulations for HW3 Thursday: Brief lecture then complete Simulations/HW

Bean, 2007, Nature Reviews Neuroscience

Action potentials carry information in the nervous system: Rate Pattern Waveform

Rate Coding in neural systems Encoding visual information in the brain:

Action potentials carry information in the nervous system:

Action potentials carry information in the nervous system: You will build cells that do this

Bean, 2007, Nature Reviews Neuroscience

Today we are interested in: What is threshold? (What determines when the cell fires) Understanding the dynamics of I V and G during the action potential What causes AHP? (how might this affect firing rate?) How is action potential width controlled? How do Na+ and K+ conductances shape firing patterns

Bean, 2007, Nature Reviews Neuroscience Different action potentials at different areas of the cell. Soma vs. Presynaptic terminal – right before the cell sends its signal to the next cell in line!!! Bean, 2007, Nature Reviews Neuroscience

gK=2 gK=1

INa = (Vm – ENa) x GNa

Right now: All we have is a cell that doesn’t encode much of anything

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