Presynaptic localization of CB1 cannabinoid receptors in the amygdala.

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Presynaptic localization of CB1 cannabinoid receptors in the amygdala. Presynaptic localization of CB1 cannabinoid receptors in the amygdala. A, B, Serial sections cut from a CB1-immunoreactive axon terminal (labeled by anasterisk) forming a symmetrical synapse (thick arrow) on a cell body in the basal nucleus of the amygdala. Note that gold particle labeling is restricted to the inner surface of the bouton, where the intracellular C terminus epitope of CB1 is located. C, High-power electron micrograph from the basal nucleus depicts that a CB1-immunoreactive bouton (white asterisk) forms a symmetrical synapse with its postsynaptic target. In this experiment, immunoperoxidase procedure was used taking advantage of its higher sensitivity. The black reaction product within the axon terminal demonstrates the CB1 immunopositivity of the bouton. In contrast, the complete lack of staining in an axon terminal (b), forming asymmetrical synapse, suggests that glutamatergic axons do not contain CB1 receptors. D, E,Combined immunogold-immunoperoxidase double staining for CB1 receptor (gold particles labeled by small arrows) and CCK (the DAB end product of immunoperoxidase reaction is depicted byasterisk) confirms that the axon terminals of CCK-containing interneurons in the basal nucleus bear presynaptic CB1 receptors. Compare the CB1/CCK double-immunopositive bouton forming a symmetrical synapse (thick arrow) with the double-immunonegative axon terminals (b1, b2), which give asymmetrical synapses (arrowheads) onto the same dendritic shaft. Scale bars: A–E, 0.5 μm. István Katona et al. J. Neurosci. 2001;21:9506-9518 ©2001 by Society for Neuroscience