Lucas G. Fernandez, MD, DSc, Timothy D

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Presentation transcript:

Differential vascular growth in postpneumonectomy compensatory lung growth Lucas G. Fernandez, MD, DSc, Timothy D. Le Cras, PhD, Mirta Ruiz, MD, David K. Glover, PhD, Irving L. Kron, MD, Victor E. Laubach, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 133, Issue 2, Pages 309-316 (February 2007) DOI: 10.1016/j.jtcvs.2006.09.003 Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, Changes in lobe weight index after pneumonectomy (PNX). Lobe weight index was significantly increased in all lobes 21 days after pneumonectomy versus that seen in the sham group (*P < .01). B, Changes in lobe volume index 21 days after pneumonectomy. Lobe volume index was significantly increased in all lobes after pneumonectomy versus that seen in the sham group (*P < .05). Percentages of increase over the sham group are included in parentheses. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 309-316DOI: (10.1016/j.jtcvs.2006.09.003) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Changes in lobe arterial area index 21 days after pneumonectomy (PNX). A, Representative arteriograms of the 4 right lung lobes after sham and pneumonectomy operations. U, Upper lobe; M, middle lobe; L, lower lobe; C, cardiac lobe. B, Arterial area index, measured by means of arteriography, was significantly increased in all lobes after pneumonectomy versus sham operations (*P < .05), indicating an increase in overall vascular area (white areas) seen in each lobe of the pneumonectomy group. In the pneumonectomy group the upper lobe displayed a significant increase in arterial area index compared with the lower and cardiac lobes (#P < .05). Percentages of increase over the sham group are included in parentheses. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 309-316DOI: (10.1016/j.jtcvs.2006.09.003) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Changes in length of arterial branch segments in the upper lobe 21 days after pneumonectomy (PNX). A, An example of arteriograms of the right upper lobe after pneumonectomy and sham operations (4× magnification). The length between the upper lobe artery and the first branch (segment A) and the length between the first and second branches (segment B, arrows) were measured. B, Histogram showing that lengths of segment A (*P < .0001 vs sham) and segment B (#P = .0294 vs sham) are significantly increased after pneumonectomy. Percentages of increase over the sham group are included in parentheses. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 309-316DOI: (10.1016/j.jtcvs.2006.09.003) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Changes in relative distribution of pulmonary blood flow after pneumonectomy. By using radiolabeled microspheres, relative blood flow (expressed as a percentage of total flow in the right lung) was determined in each lobe at the indicated times after pneumonectomy and compared with blood flow in animals not undergoing operations (0-minute time point). Relative blood flow was maintained immediately after pneumonectomy in each lobe (10-minute time point), with little change occurring thereafter. Relative blood flow in each lobe was not significantly different compared with that seen in animals not undergoing operations. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 309-316DOI: (10.1016/j.jtcvs.2006.09.003) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Changes in proliferating cell nuclear antigen (PCNA) expression in the right lung lobes after left pneumonectomy. A, Representative Western blots for proliferating cell nuclear antigen expression (36 kd) in each lobe at days 0, 7, and 21 after pneumonectomy. B, Western blot of actin (43 kd) expression in the middle lobe at 7 and 21 days after pneumonectomy versus that seen in animals not undergoing operations, documenting that surgical intervention did not alter actin expression. C, Histogram showing quantitation of proliferating cell nuclear antigen expression (as relative proliferating cell nuclear antigen/actin index) by means of Western blotting in each lobe at 7 and 21 days after pneumonectomy compared with corresponding lobes from animals not undergoing operations. Proliferating cell nuclear antigen expression was significantly increased in each lobe after pneumonectomy, with peak levels occurring at day 7 for each lobe (*P < .05 vs day 0). In addition, the upper lobe maintained a greater relative increase in proliferating cell nuclear antigen at day 21 (*P < .05 vs day 0). The Journal of Thoracic and Cardiovascular Surgery 2007 133, 309-316DOI: (10.1016/j.jtcvs.2006.09.003) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions