Intermediary pathways to synthesis of pyruvate Intermediary pathways to synthesis of pyruvate. 1, Pyruvate phosphate dikinase (132, 141); 2, pyruvate kinase (271) (the relative roles of pyruvate phosphate dikinase and pyruvate kinase in the conversion of phosphoenolpyruvate to pyruvate have not been determined); 3, phosphoenolpyruvate carboxyphosphotransferase; 4, malate dehydrogenase (188,285); 5, malate dehydrogenase (decarboxylating) (188,294); 6, alanine transaminase (72, 263); 7, aspartate transaminase (215). Intermediary pathways to synthesis of pyruvate. 1, Pyruvate phosphate dikinase (132, 141); 2, pyruvate kinase (271) (the relative roles of pyruvate phosphate dikinase and pyruvate kinase in the conversion of phosphoenolpyruvate to pyruvate have not been determined); 3, phosphoenolpyruvate carboxyphosphotransferase; 4, malate dehydrogenase (188,285); 5, malate dehydrogenase (decarboxylating) (188,294); 6, alanine transaminase (72, 263); 7, aspartate transaminase (215). Pi, inorganic phosphate. This figure has been adapted from material presented in prior reviews (55, 215) and updated from more recent literature (see citations for individual enzymes). Rodney D. Adam Clin. Microbiol. Rev. 2001; doi:10.1128/CMR.14.3.447-475.2001