Intermediary pathways to synthesis of pyruvate

Slides:



Advertisements
Similar presentations
Chapter 26 Amino Acids Metabolism.
Advertisements

Gluconeogenesis (formation of new sugar) 1. Why gluconeogenesis?
Chapter 3 Energy Metabolism and Metabolic Adaptations to Training.
CHO Metabolism. In mammals, some tissues depend almost completely on glucose for their metabolic energy The brain alone requires about 120 g of glucose.
General pathways of amino acids transformation.
Oxidative Decarboxylation and Krebs Cycle By Reem M. Sallam, M.D.; Ph.D. Clinical Biochemistry Unit, Pathology Dept. College of Medicine, King Saud University.
Gluconeogenesis.
ANABOLIC FUNCTION OF KREBS CYCLE. 2 2 Fatty acids Amino acids GlucoseGlucose GlucoseGlucose Heme Fatty acids Glucose Amino acids.
Gluconeogenesis How to synthesize glucose from noncarbohydrate precursors? p.543.
Lactate Lactate dehydrogenase Pyruvate + NADH ATP Pyruvate carboxylase ADP Oxaloacetate GTP phosphoenolpyruvate carboxykinase GDP Phosphoenol pyruvate.
Page 584 Glycolysis and TCA cycle: final accounting based on ~2.5 ATP/NADH and 1.5 ATP/FADH2 ~32 ATP/(glucose oxidized to 6CO2) Text – Figures, pg. 584.
Biosynthesis of monomers Glucose synthesis from organic compounds –Process is called gluconeogenesis –Most cells can carry out gluconeogenesis from phosphoenolpyruvate.
Cellular Respiration Part 1 Harvesting Chemical Energy from Glucose.
Undergraduate Level Notes. Mesophyll Cell Bundle Sheath Cell Vascular Tissue Overview CCM works on the basis of spatial separation of CO 2 drawdown and.
Differential flux analysis of central carbon metabolism. Fluxes which differ by less than 10% between conditions were considered constitutive.
Gluconeo- genesis Carbohydrates provide a significant portion of human caloric intake.
Gluconeogenesis.
Catabolism of amino acids
Glycolysis and Gluconeogenesis
TRICARBOXYLIC ACID CYCLE (TCA)
GLUCONEOGENESIS Synthesis of glucose from noncarbohydrate precursors
Amino acid metabolism Metabolism of amino acids differs, but 3 common reactions: Transamination Deamination Decarboxylation.
3 HPr phosphorylation by HPrK/P in the presence of Pi and (A) FBP or (B) PEP. The reaction medium was as in Fig. 2 with 1 mM ATP. The reaction medium contained.
Acetyl-CoA and the Citric Acid Cycle
Amino Acid Metabolism.
Citric Acid Cycle The citric acid cycle is the final common pathway for the oxidation of carbohydrate, lipid, and protein because glucose, fatty acids,
MBG304 Biochemistry Lecture 7: Gluconeogenesis
d-Lactic Acidosis and Selected Cerebellar Ataxias
Step 8: Migration of the Phosphate
Biochemistry of Metabolism Glycolysis
You Down With ETC? Yeah, You Know D!
Figure 4 Immune regulatory roles of glycolytic intermediates
Cellular Respiration Video
Metabolic Flux and the Regulation of Mammalian Cell Growth
Itraconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.
HL Respiration Introduction
Mechanisms by which microbial cells might develop resistance
Volume 22, Issue 5, Pages (March 2012)
Approximate numbers of cases per 100,000 individuals caused by penicillin resistance for each year (left). Approximate numbers of cases per 100,000 individuals.
Relative abundances of Propionibacterium species in different skin areas determined by 16S rRNA gene sequence analysis of 10 individuals. Relative abundances.
Major pathways of energy metabolism in mitochondria of the free-living annelid polychaete Arenicola marina (lugworm or sandworm). Major pathways of energy.
Glucose concentration-dependent increase of melanin synthesis.
Increasing prevalence of multidrug resistance among P
Results of in vivo competition experiments in a mouse model of systemic infection (median CI values are shown by horizontal lines). Results of in vivo.
Number of outbreaks associated with drinking water by water system type and year (n = 780), 1971 to “Other” includes outbreaks associated with bottled.
Percentages of outbreak deficiencies (n = 671) in public water systems (n = 656) by time period, 1971 to 2006, excluding outbreaks associated with Legionella.
Mechanism of macrophage apoptosis caused by H. pylori.
(Top) Graph illustrating citations in books for Plasmodium falciparum and Plasmodium vivax from 1900 to 2008, generated by use of the tool at
Christopher D. Wiley, Judith Campisi  Cell Metabolism 
Number of outbreaks associated with drinking water by system type and month (n = 762), 1971 to 2006, excluding outbreaks associated with commercially bottled.
Summary of the distribution and genetic context of the OXA-type enzymes in Acinetobacter baumannii. Summary of the distribution and genetic context of.
Fabrizio Dutly, and Martin Altwegg Clin. Microbiol. Rev. 2001; doi:10
Plasmodium knowlesi infections reported in humans and macaques and limits of natural distribution of mosquito vectors and of macaques. Plasmodium knowlesi.
Hector H. García et al. Clin. Microbiol. Rev. 2002; doi: /CMR
Publications on biosensors for the field in general compared with the specific detection of whole bacteria. Publications on biosensors for the field in.
Major pathways of compartmentalized energy metabolism in bloodstream (a) and procyclic (b) life cycle stages of the flagellated and fully oxygen-dependent.
Sources of energy and building blocks in oxidatively stressed D
Carbohydrate transport and phosphorylation by the PTS and their coupling to glycolysis. Carbohydrate transport and phosphorylation by the PTS and their.
Roberta B. Carey et al. Clin. Microbiol. Rev. 2018; doi: /CMR
Biogenesis of the Legionella-containing vacuole (LCV).
Schematic representation of 5′→3′ exonuclease cleavage of a 5′-labeled (small black star) probe with a 3′-phosphate (grey circle) extension blocker. Schematic.
Wax ester fermentation in mitochondria of the facultatively anaerobic photosynthetic flagellate Euglena gracilis. Wax ester fermentation in mitochondria.
Enzymatic pathway for the synthesis ofN-acetylgalactosamine, the major carbohydrate portion of the cyst wall. Enzymatic pathway for the synthesis ofN-acetylgalactosamine,
Pathogenesis of oncogenic HPV
Major pathways of energy metabolism in mitochondria of the peanut worm, Sipunculus nudus. Major pathways of energy metabolism in mitochondria of the peanut.
Eric Verdin, Melanie Ott  Molecular Cell 
The pathways of central metabolism.
Major metabolic pathways in the anaerobic intestinal parasite Entamoeba histolytica, a parasitic amoeboid protist and the causative agent of amoebiasis.
Different signaling pathways of TLR2, Nod, and TNFR1 in response to ligand, resulting in activation of NF-κB, the nuclear transcriptional factor responsible.
Amino acid substitutions in SHV ESBL derivatives.
Presentation transcript:

Intermediary pathways to synthesis of pyruvate Intermediary pathways to synthesis of pyruvate. 1, Pyruvate phosphate dikinase (132, 141); 2, pyruvate kinase (271) (the relative roles of pyruvate phosphate dikinase and pyruvate kinase in the conversion of phosphoenolpyruvate to pyruvate have not been determined); 3, phosphoenolpyruvate carboxyphosphotransferase; 4, malate dehydrogenase (188,285); 5, malate dehydrogenase (decarboxylating) (188,294); 6, alanine transaminase (72, 263); 7, aspartate transaminase (215). Intermediary pathways to synthesis of pyruvate. 1, Pyruvate phosphate dikinase (132, 141); 2, pyruvate kinase (271) (the relative roles of pyruvate phosphate dikinase and pyruvate kinase in the conversion of phosphoenolpyruvate to pyruvate have not been determined); 3, phosphoenolpyruvate carboxyphosphotransferase; 4, malate dehydrogenase (188,285); 5, malate dehydrogenase (decarboxylating) (188,294); 6, alanine transaminase (72, 263); 7, aspartate transaminase (215). Pi, inorganic phosphate. This figure has been adapted from material presented in prior reviews (55, 215) and updated from more recent literature (see citations for individual enzymes). Rodney D. Adam Clin. Microbiol. Rev. 2001; doi:10.1128/CMR.14.3.447-475.2001