Structure of an exporter.

Slides:

Advertisements

Similar presentations

Bacterial Multidrug ABC Transporter Study by Roger J. P. Dawson and Kaspar P. Locher Presented by Shaun Hug.

Advertisements

Vishwanath Jogini, Benoît Roux Biophysical Journal

Jue Chen, Gang Lu, Jeffrey Lin, Amy L Davidson, Florante A Quiocho

A Dynamin Mutant Defines a Superconstricted Prefission State

Inferring chromatin organization.

Mechanism of PRPP-mediated regulation of transcription by PyrR and PurR. Mechanism of PRPP-mediated regulation of transcription by PyrR and PurR. PyrR.

Overview of predicted carbohydrate uptake and metabolism systems in bifidobacteria. Overview of predicted carbohydrate uptake and metabolism systems in.

Frequency of inactivated spores of B

Shielding of bacterial spores against galactic cosmic radiation by meteorite material. Shielding of bacterial spores against galactic cosmic radiation.

Three-dimensional structure of B. subtilis PRPP synthase.

Allosteric site of B. subtilis PRPP synthase.

Cross-section of a spore of B. subtilis.

The microsporidian sex-related locus.

Solar spectrum in space (thin line) and on Earth's surface (thick line). Solar spectrum in space (thin line) and on Earth's surface (thick line). Below.

Molecular-Dynamics Simulations of the ATP/apo State of a Multidrug ATP-Binding Cassette Transporter Provide a Structural and Mechanistic Basis for the.

N-Glycosidic bond formation with PRPP

Phrap assemblies visualized with the Consed (53) program.

Current models of the interactions of proteins within β-carboxysomes.

Possible secondary structure of the S. enterica prs leader.

The proline in R347P destabilizes TM6.

Schematic representation of major cell wall components.

A Different Look for AB5 Toxins

Alignments of the complete genome sequences of the B

A YidC-like Protein in the Archaeal Plasma Membrane

Representative protein structures for bacterial PPIases.

Volume 24, Issue 12, Pages (December 2016)

Model for T4P assembly. Model for T4P assembly. (A) Side view of the inner membrane assembly platform. In the pilus assembly cycle shown, a single pilin.

Summary of major events in Earth history relating to the appearance of eukaryotic groups and the appearance of O2 in the atmosphere and in marine environments.

Functions of type 3 fimbriae during K

Structure of CD94 Reveals a Novel C-Type Lectin Fold

Volume 21, Issue 5, Pages (May 2013)

Drug transport mechanism of AcrB.

Structures of P. aeruginosa ExoU and its chaperone, SpcU (PDB ID 3TU3), shown as a cartoon. Structures of P. aeruginosa ExoU and its chaperone, SpcU (PDB.

Selectivity-determining regions

Schematic representation of the hydrolysis of amorphous and microcrystalline cellulose by noncomplexed (A) and complexed (B) cellulase systems. Schematic.

Antibiofilm strategies arising from fundamental research.

UV resistance of spores and vegetative cells of B

Scheme for recovery of viral nucleic acid from microarray spots.

Molecular model of C. pseudotuberculosis Smase D

Physiological effects of heat shock.

Fig. 2 Cardiolipin binding sites in complex I.

Simplified neighbor-joining tree of ABC domains.

Prophage genome map of the C. diphtheriae prophage encoding DT

Undecaprenyl-linked O antigen polysaccharide precursors (O-PS), initiated by a WecA homologue and elongated at the nonreducing end (black dots), are polymerized.

Molecular models for module exchange between phages.

MEED exposure facility mounted on the camera beam of the lunar orbiter of the Apollo 16 mission (A) and sample cuvette for exposing dry layers of microorganisms.

Structures of four importers.

Binding of mRNA to the 30S ribosomal subunit.

Modeling of EGFR exon 20 insertions using the 3-dimensional structure of the EGFR kinase domain predicts different interactions with the erlotinib-binding.

Simple CRP regulation operates through two related mechanisms, designated class I and class II. Both classes depend on specific interactions between CRP.

Concerted model for maltose transport.

Mechanisms of XRV and ERV transmission.

Incorporation of new cell wall in differently shaped bacteria.

Structural features of seven streptococcal cell surface proteins that function in adherence and colonization. Structural features of seven streptococcal.

General scheme of the events triggered by C

Conserved motifs in the ABC

Absorption spectra of PRs in relation to light attenuation patterns in different marine environments. Absorption spectra of PRs in relation to light attenuation.

Thermodynamic cycle for ligand binding to a periplasmic-BP.

Model of transition to extant bipolar systems from an ancestral tetrapolar system in basidiomycete MAT loci. Model of transition to extant bipolar systems.

Intrastrand biases (nucleotide skew) in the T4 genome.

Structures of T4 pilins and minor pilins.

Schematic view of the organization of transport systems.

General overview of the bioinformatic pipelines for the 16S rRNA gene microbial profiling and shotgun metagenomics. General overview of the bioinformatic.

Repair kinetics of radiation-induced DNA damage under microgravity conditions. Repair kinetics of radiation-induced DNA damage under microgravity conditions.

IF2 and structural homologues.

Sequence alignment of colicin lysis proteins.

Models of pilus and pseudopilus fibers.

Molecular model of the Helicobacter pylori PldA1 dimer.

Structure of an ATP-bound ABC dimer.

Actin tails formed by Rickettsia spp.

Presentation transcript:

Structure of an exporter. Structure of an exporter. Sav1866 is a homodimer of two IM-ABC subunits. IM domain 1 (green) is fused to NBD1 (blue), and IM domain 2 (red) is fused to NBD2 (yellow). Bound ADP is represented with a ball-and-stick model. The front view (left) reveals a cleft in the IM region that would be exposed to the outer leaflet of the lipid bilayer. TM helices are predicted to extend well into the cytoplasm, creating an ICD. The side view (right) reveals the intertwisting of TM helices that places the coupling helix of one subunit into the cleft of the NBD of the second subunit in an example of domain swapping. Amy L. Davidson et al. Microbiol. Mol. Biol. Rev. 2008; doi:10.1128/MMBR.00031-07