Antihistamine premedication in specific cluster immunotherapy: A double-blind, placebo- controlled study Lone Nielsen, MD, Claus R. Johnsen, MD, Holger.

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Presentation transcript:

Antihistamine premedication in specific cluster immunotherapy: A double-blind, placebo- controlled study Lone Nielsen, MD, Claus R. Johnsen, MD, Holger Mosbech, MD, Lars K. Poulsen, PhD, Hans-Jørgen Malling, MD Journal of Allergy and Clinical Immunology Volume 97, Issue 6, Pages 1207-1213 (June 1996) DOI: 10.1016/S0091-6749(96)70186-0 Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 A, Number of SRs versus injections to reach maintenance dose for the 20 patients in the loratadine group and 17 patients in the placebo group who reached the maintenance dose of 100,000 SQ-U. B, Number of SRs for patients who did not reach maintenance dose (loratadine, 1 patient; placebo, 7 patients). Open triangles, placebo; filled triangles, loratadine. Journal of Allergy and Clinical Immunology 1996 97, 1207-1213DOI: (10.1016/S0091-6749(96)70186-0) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Median diameter of LRs after immunotherapy at different time intervals. Open triangles, Placebo; filled triangles, loratadine. Parameters were assessed by the exact two-sample Wilcoxon rank-sum test (Mann-Whitney). *p < 0.05, **p < 0.01, ***p < 0.001. Journal of Allergy and Clinical Immunology 1996 97, 1207-1213DOI: (10.1016/S0091-6749(96)70186-0) Copyright © 1996 Mosby, Inc. Terms and Conditions