Rebound Vertebral Fractures in a Patient With Lung Cancer After Oncology-Dose Denosumab Discontinuation: A Cautionary Tale Alexander Tyan, MD, Sandip.

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Rebound Vertebral Fractures in a Patient With Lung Cancer After Oncology-Dose Denosumab Discontinuation: A Cautionary Tale Alexander Tyan, MD, Sandip Pravin Patel, MD, Shanna Block, PharmD, BCOP, Tudor Hughes, MD, FRCR, Karen C. McCowen, MD, MRCPI Mayo Clinic Proceedings: Innovations, Quality & Outcomes Volume 3, Issue 2, Pages 235-237 (June 2019) DOI: 10.1016/j.mayocpiqo.2019.02.003 Copyright © 2019 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure Sagittal reconstruction of the thoracic and lumbar spines from computed tomographic scans of the thorax and abdomen/pelvis, initially and 4 months later. The images demonstrate the evolution of the fractures from August 2017 (A and C) through December 2017 (B and D) at T6, T9, T12, L1, L2, L3, and L4, with a combination of sclerosis, principally at the superior end plates, and loss of vertebral height. The images were obtained using the Revolution CT (GE Healthcare) (displayed at 3.75 mm thick, reconstructed from 0.625-mm helical acquisition and on a bone algorithm of width 2000 and level 500). Mayo Clinic Proceedings: Innovations, Quality & Outcomes 2019 3, 235-237DOI: (10.1016/j.mayocpiqo.2019.02.003) Copyright © 2019 Mayo Foundation for Medical Education and Research Terms and Conditions