The truncating mutation c

Slides:

Advertisements

Similar presentations

The Build-up of the Red Sequence at z

Advertisements

22 kDa a-coixin gene cluster

Odds ratios for change in PD from earliest mammogram within levels of earliest PD. No evidence for an interaction of earliest PD and change in PD on breast.

CYB561 mutations. CYB561 mutations. The upper part shows the structure of the CYB561 gene, with the positions of the identified mutations indicated. Gray.

Flow diagram of the literature search and selection process in the PubMed and Scopus databases. Flow diagram of the literature search and selection process.

Line graph of preoperative saliva samples and cancerous tissue that were methylated at specific gene loci. Line graph of preoperative saliva samples and.

A: OAZ1 mRNA transcript of 775-1, and parental cell lines showing the stop codon introduced by the nonsense mutations in the and transcripts,

cpDNAs with large deletions accumulate in cptk1 mutants.

Variability in protein concentration of urine over a 10-d collection from a single healthy volunteer. Variability in protein concentration of urine over.

miRNA expression patterns in stools from healthy subjects.

Characterization of oprD promoter elements.

HPLC analysis of the glucosinolate composition of the broccoli sprouts (A) and placebo (C) beverages prepared from the first and fourth aqueous extracts.

Clinically significant precounseling cancer distress modifies counseling method's effect on testing uptake. *, statistically significant difference observed.

Translate 5 squares left and 4 squares up.

Risk of PTC associated with serum concentrations of TSH and thyroid hormones among females, stratified by tumor size. *, Conditional logistic regression,

Multiplexed Mutagenesis Using the Csy4 System in Tomato Protoplasts.

Editing of ADE2 in C. metapsilosis.

Fig. 2 Cas9/RecA-mediated in vivo gene correction of Pde6b.

Activating mutation of Ras is associated with CDCP1 expression in NSCLC. A, NSCLC cell lines with Ras + B-Raf mutations and wild-type Ras were examined.

LD structure of the TOX3/LOC region in HapMap CEU and YRI populations.

The power to detect an OR of 2

Histopathologic characteristics in HL-mice and HL-HPS-mice.

Scatterplot and LD map of the genotyped tagging SNPs along the TOX3/LOC region. Scatterplot and LD map of the genotyped tagging SNPs along the TOX3/LOC

Meta-analysis of five prospective studies examining the associations between urinary melatonin secretion and breast cancer risk. Meta-analysis of five.

Integrated mRNA and microRNA expression and DNA methylation clusters.

Increased levels of branching on serum glycoproteins from patients with HCC. A, focus on larger branched glycans from 4 representative cirrhotics, and.

Regional plot and genome browser view of 14q13.

Heat map of genes for which CR significantly altered expression versus AL. Cluster analysis of genes significantly changed by the CR intervention compared.

Multivariate-adjusted breast density means for joint relation of IGF-I with IGFBP-3 in premenopausal women. Multivariate-adjusted breast density means.

Analysis of studies that examined the association between diabetes mellitus and prostate cancer. Analysis of studies that examined the association between.

Risk (aOR) of breast cancer associated with the combination of putative at-risk genotypes of the MRN genes and the reproductive risk factors of a history.

Age-adjusted breast cancer incidence rates in females by age-adjusted HD incidence rates in females 15–34 years of age in 135 populations in the world.

Constitutive characteristics in HL-mice and HL-HPS-mice.

The I1307K APC gene variant was identified using primers designed to detect the I1307K. The I1307K APC gene variant was identified using primers designed.

Excerpts of identified gene expression profiles.

Age-adjusted incidence and mortality rates by race for breast cancer (all ages, females, SEER 9 registries for , age adjusted to the 2000 United.

Parity explains the age-associated increase in ANA prevalence in women ages 12 to 59 years, but not in those ages 60+. Parity explains the age-associated.

Distributions of CD4, Th1, and Th2 in adults (n = 16; A) and children (n = 50; B). Distributions of CD4, Th1, and Th2 in adults (n = 16; A) and children.

Gene copy number analysis by multiplexed quantitative differential PCR for BRCA1 and BRCA2 for 23 DNA specimens obtained from patients of Hispanic ancestry.

BRCA1 del (ex 9-12) haplotype.

Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. Endogenously produced n-3 PUFAs inhibit endometrial cancer.

Darryl Y. Nishimura, Ruth E. Swiderski, Charles C. Searby, Erik M

N-Linked glycosylation of total protein from representative HCC tissue and adjacent liver tissue. N-Linked glycosylation of total protein from representative.

Mass spectrometry identification of biomarker candidates in the prediagnostic plasmas in the Women's Health Initiative cohort. Mass spectrometry identification.

Analysis of mRNA and protein levels of Loricrin, COMP, CXCL9, KRT19, and CYP 3A5 genes in OSFs compared with normal controls. Analysis of mRNA and protein.

Kaplan-Meier survival analysis of p53 mutation in the overall breast tumor series. Kaplan-Meier survival analysis of p53 mutation in the overall breast.

Categories of system-based chronic and late medical and neuropsychologic health events graded in the SJLIFE study. Categories of system-based chronic and.

One-way hierarchical cluster analysis of SAM-identified genes using the TMEV software to see the data substructure. One-way hierarchical cluster analysis.

Association of MTR A2756G with risk of localized and advanced prostate cancer: dominant model comparing (G/G and A/G) versus A/A genotypes (I-V, inverse-variance.

The long tail of mutational hotspots in cancer.

A and B, two blocks from the original specimen used for TMA demonstrated areas with varying patterns of ALK rearrangement and KRAS mutation status. A and.

GATA-3 immunostaining was scored semiquantitatively; tumors with

ROC analysis of MIC-1 and CA19-9.

Molecular definitions of lung adenocarcinoma subtypes.

Rapid autopsy reveals interlesional and intralesional heterogeneity of resistance. Rapid autopsy reveals interlesional and intralesional heterogeneity.

Single nucleotide polymorphism array analysis can distinguish different genetic mechanisms that lead to loss of heterozygosity (LOH). Single nucleotide.

A, Proportion for different in silico predictions at the RNA level.

The pattern of association between all-cancer mortality risk and long-term exposure to PM2.5 (μg/m3). The pattern of association between all-cancer mortality.

Individuals affected with cancer included in the Lynch syndrome are colored. Individuals affected with cancer included in the Lynch syndrome are colored.

Predicted pathogenic BRCA1 amino acid substitutions are confined to the evolutionarily conserved N- and C-terminal domains. Predicted pathogenic BRCA1.

A, Schematic diagram of identified splice variants of PD-L1.

Quantile–quantile plots of 42 interaction P values for seven SNPs under investigation. Quantile–quantile plots of 42 interaction P values for seven SNPs.

Pooled effect of exercise on glucose, IR, IGF1, and IGFBP3 in breast cancer survivors. Pooled effect of exercise on glucose, IR, IGF1, and IGFBP3 in breast.

Comparison of the van gene clusters.

Driver pathways and key genes in OSCC

Mutant TERT promoter displays active histone marks and distinct long-range interactions: A, cell lines that were used in the study with their origin and.

BRCA1 protein functional domains and predicted frameshift and premature truncation. BRCA1 protein functional domains and predicted frameshift and premature.

Schematic representation of the HPV genome, highlighting the regions important in PCR-based HPV analysis. Schematic representation of the HPV genome, highlighting.

Epithelial and stromal percentage clusterin staining in normal nonadjacent colonic tissue and matched tumor tissue in 202 patients with stage II colorectal.

Fig. 3 Genome editing of the MSTN gene.

Presentation transcript:

The truncating mutation c The truncating mutation c.661_662delGTinsTA that introduced a TAA stop codon into position 221 in the PALB2 gene identified by sequencing (left) and PTT (right). The truncating mutation c.661_662delGTinsTA that introduced a TAA stop codon into position 221 in the PALB2 gene identified by sequencing (left) and PTT (right). Truncated polypeptide is indicated by a red arrowhead; wild-type (WT) translation product is indicated by a blue arrowhead; C–WT control. Marketa Janatova et al. Cancer Epidemiol Biomarkers Prev 2013;22:2323-2332 ©2013 by American Association for Cancer Research