Analysis of Differentially Expressed Genes in Neuroendocrine Carcinomas of the Lung Chigusa Okubo, MS, Yuko Minami, MD, Ryota Tanaka, MD, Teruhito Uchihara,

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Analysis of Differentially Expressed Genes in Neuroendocrine Carcinomas of the Lung Chigusa Okubo, MS, Yuko Minami, MD, Ryota Tanaka, MD, Teruhito Uchihara, MD, Yoichi Anami, MD, Shuichiroh Furuya, BA, Yukio Morishita, MD, Tatsuo Iijima, MD, Masayuki Noguchi, MD Journal of Thoracic Oncology Volume 1, Issue 8, Pages 780-786 (October 2006) DOI: 10.1016/S1556-0864(15)30406-8 Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Histological appearance of a case of LCNEC (case 8, a) and a mouse Lu139 tumor (b). The LCNEC showed neuroendocrine morphology (e.g., organoid nesting, palisading, and trabeculae). The mouse tumor showed diffuse growth of small tumor cells with a high N/C ratio, mimicking human SCLC. (H.E.; original magnification, ×200.) Journal of Thoracic Oncology 2006 1, 780-786DOI: (10.1016/S1556-0864(15)30406-8) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Immunohistochemical staining for NNAT in LCNEC and SCLC. Areas showing NE morphology, such as palisading or rosette formation, were negative for the antibody (case 8, a), but poorly differentiated areas showed positive reaction (case 3, b). All cases of SCLC were negative (e.g., case 20, c) except for case 16 (d), which contained partially positive cells (arrows). (Original magnification, ×200.) Journal of Thoracic Oncology 2006 1, 780-786DOI: (10.1016/S1556-0864(15)30406-8) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions