Examining the Role of Pharmacokinetics in Hemophilia

Role of PK Studies in Patients With Hemophilia

The Science of Pharmacokinetics

Pharmacokinetics

Pharmacokinetic Definitions

Hemophilia Overview

Intermittent Infusions (Bolus)

Continuous Infusions

Half-Life Differences With Types of Factor VIII Deficiency Treatments

Available Extended Half-Life Products for Factor VIII

Half-Life Differences With Types of Factor IX Deficiency Treatments

Available Extended Half-Life Products for Factor IX

Assays for Hemophilia

Factor Dosing General Overview

Clinical Implications of PK Studies in Hemophilia Management

Clinical Implications of PK Studies in Hemophilia Treatment

PK Studies Optimize Treatment

Personalized Prophylaxis

Challenges of PK Studies

Practical Approaches to PK Studies Peak/Trough Levels

Practical Approaches to PK Studies Population PK Studies

Planning Regimen With Patient/Family Factors to Consider

Patient/Family Education

Patient/Family Education and Participation

Practical Implementation

Role of Nurses and Pharmacists in PK Assessment

Comprehensive Hemophilia Care Team

Role of the HTC Team Pharmacist

Role of the HTC Team Nursing

Role of HTC Team (cont)

Closing the Loop

Abbreviations