Induction of cytotoxic activity in humanized SCC3 tumor-bearing mice treated with anti-PD-1 antibody. Induction of cytotoxic activity in humanized SCC3.

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Induction of cytotoxic activity in humanized SCC3 tumor-bearing mice treated with anti-PD-1 antibody. Induction of cytotoxic activity in humanized SCC3 tumor-bearing mice treated with anti-PD-1 antibody. A, CTL induction against SCC3 cells from three spleens of anti-PD-1–treated mice. Levels of IFNγ produced by CTL cells stimulated with irradiated SCC-3 cells were measured using an ELISA Kit. Open column, control group; closed column, anti-PD-1–treated group. B, NK-cell cytotoxic activity of three spleens from anti-PD-1–treated mice. Cytotoxic activity was measured using the Nonradioactive Cytotoxicity Assay Kit. C, control group; T, anti-PD-1–treated group. Each column represents the mean value of the triplicate experiments. Tadashi Ashizawa et al. Clin Cancer Res 2017;23:149-158 ©2017 by American Association for Cancer Research