Complications and sequelae related to severe forms of chromoblastomycosis. Complications and sequelae related to severe forms of chromoblastomycosis. (A)

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Complications and sequelae related to severe forms of chromoblastomycosis. Complications and sequelae related to severe forms of chromoblastomycosis. (A) Chronic lymphedema hyperkeratotic lesions in the upper limb. (B) Ectropium, secondary bacterial infection, and facial lymphedema. (C) Ankylosis of the knee. (D) Neoplastic transformation of a foot lesion. Shown is an ulcerative lesion with chronic bacterial infection. (E) Skin biopsy specimen taken 80 months later showing a well-differentiated epidermoid carcinoma with typical nuclear atypias and “corn pearls” in the middle of neoplastic cell blocks. Shown is an HE-stained section at a ×400 magnification. (F) Vegetant and papillomatous lesions resulting from the association of chromoblastomycosis with neoplastic lesions. Flavio Queiroz-Telles et al. Clin. Microbiol. Rev. 2017; doi:10.1128/CMR.00032-16