Jeffrey T Cope, MD, Michael C Mauney, MD, David Banks, BS, Oliver A

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Presentation transcript:

Intravenous Phenylephrine Preconditioning of Cardiac Grafts From Non–Heart-Beating Donors Jeffrey T Cope, MD, Michael C Mauney, MD, David Banks, BS, Oliver A.R Binns, MD, Christopher L Moore, BS, Jeffrey J Rentz, BS, Kimberly S Shockey, MS, R.Christoper King, MD, Irving L Kron, MD, Curtis G Tribble, MD The Annals of Thoracic Surgery Volume 63, Issue 6, Pages 1664-1668 (June 1997) DOI: 10.1016/S0003-4975(97)00092-1

Fig. 1 Non–heart-beating donor protocols. (PE = phenylephrine.) The Annals of Thoracic Surgery 1997 63, 1664-1668DOI: (10.1016/S0003-4975(97)00092-1)

Fig. 2 Time (minutes) required to produce hypoxic cardiac arrest after withdrawal of ventilation from non–heart-beating donors. Phenylephrine (PE) 25 μg/kg versus saline controls (SC), p = 0.005 by analysis of variance. The Annals of Thoracic Surgery 1997 63, 1664-1668DOI: (10.1016/S0003-4975(97)00092-1)

Fig. 3 Mean left ventricular developed pressures in all groups after 45 minutes of reperfusion. Nonischemic controls (NC) versus all others, p = 0.00001 by analysis of variance. Phenylephrine (PE) 25 μg/kg versus saline controls (SC), p = 0.04 by planned comparison test of hypothesis. The Annals of Thoracic Surgery 1997 63, 1664-1668DOI: (10.1016/S0003-4975(97)00092-1)