Determinants of asthma after severe respiratory syncytial virus bronchiolitis Leonard B. Bacharier, MD, Rebecca Cohen, MD, Toni Schweiger, RN, Huiquing.

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life Carina Venter, BSc, Brett Pereira, MRCP, Jane.

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Advances in Diagnosing Peanut Allergy

Jonathan Malka, MD, David T

Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S

Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life Carina Venter, BSc, Brett Pereira, MRCP, Jane.

Fatty acids, inflammation, and asthma

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Jason S. Debley, MD, MPH, David C. Stamey, RRT, Elizabeth S

Robert F. Lemanske, MD, Daniel J. Jackson, MD, Ronald E

Caregivers report a wide variety of early signs and symptoms of impending asthma exacerbations that are not different between preschool and school-aged.

Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from.

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Diagnosis of red meat allergy with antigen-specific IgE tests in serum

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Is 9 more than 2 also in allergic airway inflammation?

Fatty acids, inflammation, and asthma

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Test for Respiratory and Asthma Control in Kids (TRACK): A caregiver-completed questionnaire for preschool-aged children Kevin R. Murphy, MD, Robert.

Physician needs in health informatics: Just ask the docs

Jodell E. Linder, PhD, David C

Advances in Diagnosing Peanut Allergy

Cytokine response after severe respiratory syncytial virus bronchiolitis in early life Mario Castro, MD, MPH, Toni Schweiger, RN, Huiquing Yin-DeClue,

Ganesa Wegienka, PhD, Suzanne Havstad, MA, Edward M

Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze Yanjiao Zhou,

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Cats and dogs and the risk of atopy in childhood and adulthood

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Do oral corticosteroids reduce the severity of acute lower respiratory tract illnesses in preschool children with recurrent wheezing? Avraham Beigelman,

Comparison of asthma prevalence among African American teenage youth attending public high schools in rural Georgia and urban Detroit Dennis R. Ownby,

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

What is an “eosinophilic phenotype” of asthma?

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Higher incidence of pediatric anaphylaxis in northern areas of the United States William J. Sheehan, MD, Dionne Graham, PhD, Lin Ma, MS, Sachin Baxi,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Diagnosis and management of early asthma in preschool-aged children

Geographic variability in childhood asthma prevalence in Chicago

High prevalence of severe asthma in a large random population study

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S

Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program Christy Gamble, DrPHc, MPH, Evelyn Talbott,

One step forward, 2 steps back: The enigma of preschool wheeze

Halie M. Anderson, MD, Robert F. Lemanske, MD, Michael D

Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infection Hanna Juntti, MD, Pamela Österlund, PhD, Jorma Kokkonen,

Biology of nasal polyposis

Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma Anne E. Dixon, MA, BM BCh,

Association between climate factors, pollen counts, and childhood hay fever prevalence in the United States Jonathan I. Silverberg, MD, PhD, MPH, Marc.

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A

Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial.

Measles and immunomodulation

Asthma: The past, future, environment, and costs

Matthew R. Gingo, MD, MS, Sally E

Personal and parental nativity as risk factors for food sensitization

Asthma Control Test: Reliability, validity, and responsiveness in patients not previously followed by asthma specialists Michael Schatz, MD, MS, Christine.

Caroline C. Horner, MD, MSCI, Courtney Dula, MS, Leonard B

Environmental factors and eosinophilic esophagitis

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma Theresa W. Guilbert, MD, MS, Anne Marie Singh,

Presentation transcript:

Determinants of asthma after severe respiratory syncytial virus bronchiolitis Leonard B. Bacharier, MD, Rebecca Cohen, MD, Toni Schweiger, RN, Huiquing Yin-DeClue, PhD, Chandrika Christie, MA, Jie Zheng, MS, Kenneth B. Schechtman, PhD, Robert C. Strunk, MD, Mario Castro, MD, MPH Journal of Allergy and Clinical Immunology Volume 130, Issue 1, Pages 91-100.e3 (July 2012) DOI: 10.1016/j.jaci.2012.02.010 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Enrollment and follow-up of participants through the RBEL study. Patients were enrolled during an episode of severe RSV bronchiolitis and followed prospectively through the first 6 years of life. GE, Gastroesophageal. Journal of Allergy and Clinical Immunology 2012 130, 91-100.e3DOI: (10.1016/j.jaci.2012.02.010) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Survival curves for time to development of the first 3 wheezing illnesses and physician’s diagnosis of asthma subsequent to the index RSV bronchiolitis episode. The vertical axis represents the probability of not wheezing (for times to first, second, and third wheezing episodes) or not having physician-diagnosed asthma (blue circles). Blue triangles represent the first subsequent parent-reported wheezing episode, brown triangles represent the second subsequent parent-reported wheezing episode, green triangles represent the third subsequent parent-reported wheezing episode, and blue circles represent a physician’s diagnosis of asthma. Journal of Allergy and Clinical Immunology 2012 130, 91-100.e3DOI: (10.1016/j.jaci.2012.02.010) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 ROC curves for a post-RSV Asthma Predictive Index for physician-diagnosed asthma and active asthma. A, The model for physician-diagnosed asthma, incorporating the clinically derived predictors that were significant in the univariate analyses. B, The model for physician-diagnosed asthma (red) and active asthma (blue) incorporating nasal CCL5 levels alone at enrollment. Journal of Allergy and Clinical Immunology 2012 130, 91-100.e3DOI: (10.1016/j.jaci.2012.02.010) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions