Endothelial cells/microvasucles are increased in prostate cancer versus normal tissues. Endothelial cells/microvasucles are increased in prostate cancer.

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Endothelial cells/microvasucles are increased in prostate cancer versus normal tissues. Endothelial cells/microvasucles are increased in prostate cancer versus normal tissues. A and B, IHC staining of normal prostate and prostate tumor tissues. A, human patient tissues; arrows, CD31/CD34-positive cells. B, TRAMP mouse tissues. Human normal prostate and prostate tumor tissues were obtained from young (about 30 years of age) normal organ donors and patients with radical resection of prostate cancer, respectively, at the Shanghai First People's Hospital (Shanghai, China). TRAMP tumors were obtained from 28-week-old TRAMP mice (B6 background). C, IHC staining of C4-2 orthotopic xenografted tumor tissues before (B-Cas) and after castration. C4-2 cells were orthotopically injected into anterior prostates of mice. After tumors developed, mice were castrated and castration-resistant tumors allowed to redevelop. Mice were sacrificed 10, 20, and 30 days after castration and tumors were obtained. Tumors from some mice before castration were used as controls. Tumor tissues were immunohistochemically stained with CD31 and CD34 antibodies. *, P < 0.05. Xiaohai Wang et al. Mol Cancer Ther 2013;12:1026-1037 ©2013 by American Association for Cancer Research