High-throughput siRNA screening results and corresponding patient gene expression data for PP2A subunits. High-throughput siRNA screening results and corresponding.

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High-throughput siRNA screening results and corresponding patient gene expression data for PP2A subunits. High-throughput siRNA screening results and corresponding patient gene expression data for PP2A subunits. A, PP2A subunit expression in benign prostate epithelia, ADT-resistant primary prostate tumors, and CRPC metastases. B, knockdown of PPP2R1A and PPP2R2C induce sufficient growth to reach the significance threshold in both cell lines. Knockdown of other PP2A B-regulatory subunits induced variable effects on proliferation. Dotted lines represent Z = ±1.96. Eric G. Bluemn et al. Mol Cancer Res 2013;11:568-578 ©2013 by American Association for Cancer Research